Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 양승 | - |
dc.date.accessioned | 2022-09-26T01:36:14Z | - |
dc.date.available | 2022-09-26T01:36:14Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.citation | Annals of Pediatric Endocrinology & Metabolism, v. 25, no. 4, page. 234-239 | en_US |
dc.identifier.issn | 2287-1012; 2287-1292 | en_US |
dc.identifier.uri | https://e-apem.org/journal/view.php?doi=10.6065/apem.2040020.010 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/173842 | - |
dc.description.abstract | Purpose: This study aims to investigate the effect of gonadotropin-releasing hormone agonist (GnRHa) on the growth hormone (GH)-insulin-like growth factor-1 (IGF-1) axis and to evaluate whether-202 A/C IGF binding protein-3 (IGFBP-3) promoter polymorphism affects growth velocity in females with central precocious puberty (CPP) during treatment. Methods: Data was collected from 97 females younger than 9 years, diagnosed with precocious puberty and treated with GnRHa for at least 1 year at Kangdong Sacred Heart Hospital from 2014 to 2015. Their body height, weight, change in height standard deviation score (∆SDS), serum IGF-1, serum IGFBP-3, bone age, and-202 A/C IGFBP-3 promoter polymorphism were measured before and after GnRHa treatment. The interrelationships between the variables were calculated. Results: During treatment, height SDS, IGF-1 SDS, IGFBP-3 SDS, and IGF-1/IGFBP-3 ratio significantly decreased. A significant correlation was observed between ∆IGF-1 SDS and ∆height SDS (r=0.405, P<0.001). The presence of the C allele was significantly correlated with IGF-1 SDS after treatment (P=0.049) and with IGFBP-3 SDS before and after treatment (P=0.012 and P=0.001), but not with ∆IGF-1 SDS, ∆IGFBP-3 SDS, ∆IGF-1/IGFBP-3 ratio, or ∆height SDS. Conclusions: Growth velocity during GnRHa treatment is related to ∆IGF-1 SDS, indicating the apparent impact of GnRHa on the GH-IGF-1 axis. The -202 A/C IGFBP-3 promoter polymorphism does not affect the growth velocity of GnRHa in CPP girls. | en_US |
dc.description.sponsorship | This study was financially supported by a research grant from the Investigator-Initiated Trials program of Ferring Pharmaceuticals. Opinions expressed in this paper are those of the authors and do not necessarily represent those of Ferring Pharmaceuticals. The authors would thank Ferring Pharmaceuticals for supporting this research. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Korean society of pediatric endocrinology | en_US |
dc.subject | Precocious puberty; Growth velocity; Insulin-like growth factor-1; Insulin-like growth factor binding protein-3; -202 A/C IGFBP-3; Promoter regions | en_US |
dc.title | Relationship between growth velocity and change of levels of insulin-like growth factor-1, insulin-like growth factor binding protein-3 and, igfbp-3 promoter polymorphism during gnrh agonist treatment | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 25 | - |
dc.identifier.doi | 10.6065/apem.2040020.010 | en_US |
dc.relation.page | 234-239 | - |
dc.relation.journal | Annals of Pediatric Endocrinology and Metabolism | - |
dc.contributor.googleauthor | Park, Jun-Hong | - |
dc.contributor.googleauthor | Hwang, Il-Tae | - |
dc.contributor.googleauthor | Yang, Seung | - |
dc.relation.code | 2020001536 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jxisfriend | - |
dc.identifier.orcid | https://orcid.org/0000-0002-3380-6962 | - |
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