Association between Antibiotic Consumption and Incidence of Clostridioides difficile Infection in a Hospital
- Title
- Association between Antibiotic Consumption and Incidence of Clostridioides difficile Infection in a Hospital
- Author
- 김지은
- Keywords
- Clostridioides difficile; Antibiotics; Correlation; Stewardship; Korea
- Issue Date
- 2020-12
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v. 35, no. 47, article no. 407, page. 1-6
- Abstract
- Previous exposure to antimicrobials is a major risk factor for Clostridioides difficile infection (CDI). Antibiotic prescription and C. difficile toxin assay records of patients admitted to a tertiary hospital in Korea from 2009 to 2013 were collected to investigate the association between antibiotic consumption and CDI incidence. A Spearman's correlation analysis between CDI incidence (positive result of toxin assay/10,000 admissions) and antibiotic consumption (defined daily dose/1,000 patient-days) was performed on a monthly basis. Using the matched month approach, we found a significant correlation between CDI rate and moxifloxacin consumption (Spearman's r = 0.351, P ˂ 0.001). Furthermore, using the onemonth delay approach, we found that the consumption of clindamycin (Spearman's r = 0.272, P = 0.037) and moxifloxacin (Spearman's r = 0.297, P = 0.022) was significantly correlated with CDI incidence. Extended-spectrum cephalosporins did not have any effect on CDI incidence.
- URI
- https://jkms.org/DOIx.php?id=10.3346/jkms.2020.35.e407https://repository.hanyang.ac.kr/handle/20.500.11754/173793
- ISSN
- 1011-8934; 1598-6357
- DOI
- 10.3346/jkms.2020.35.e407
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
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