Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김미미 | - |
dc.date.accessioned | 2022-09-19T01:03:39Z | - |
dc.date.available | 2022-09-19T01:03:39Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.citation | ANNALS OF TRANSLATIONAL MEDICINE, v. 8, no. 23, article no. 1583, page. 1-12 | en_US |
dc.identifier.issn | 2305-5839 | - |
dc.identifier.issn | 2305-5847 | - |
dc.identifier.uri | https://atm.amegroups.com/article/view/56340/html | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/172925 | - |
dc.description.abstract | Background: Appropriate strategy for screening, identification, and linkage to care of patients with advanced fibrosis in the general population is a current issue. The aim of this study was to find reference values and the clinical role of Mac-2 binding protein glycan isomer (M2BPGi) in a health check-up setting. Methods: This study was designed as cross-sectional study. Adult subjects (n=1,073) who underwent a health check-up were included in the final analysis, and 952 subjects with risk factors for liver disease and insufficient data were excluded. M2BPGi quantification was based on a lectin antibody sandwich immunoassay. Fatty liver was diagnosed using abdominal sonography. Results: The reference value of M2BPGi was 0.5–1.0 cut off index (COI) in the average risk group. Serum M2BPGi showed a positive correlation with metabolic parameters as well as age. Prevalence of abnormal M2BPGi (>1.0) was higher in low muscle mass (4.7%, vs. 17.4%, P=0.002), metabolic syndrome (14.2% vs. 30.4%, P=0.003), and hypertension (21.8%, vs. 58.7%, P<0.001) compared to healthy controls. M2BPGi was positively correlated with estimated fibrosis values such as FIB-4 (R=0.293, P<0.001) and NAFLD fibrosis score (R=0.248, P<0.001). Although the prevalence of advanced fibrosis in the total population was just 1.6% (FIB-4 >2.65), the prevalence of advanced fibrosis increased to 50% in the high M2BPGi (>1.0) group with diabetes. This value was 31.25 times higher than in the total population group. Conclusions: The results indicated a high possibility of advanced hepatic fibrosis in diabetic subjects with abnormal M2BPGi level (>1.0). | en_US |
dc.description.sponsorship | This study was supported by the Sysmex Company. The funding source had no role in the study design, implementation, data collection, analysis, interpretation, or in the preparation, review, or approval of the manuscript. | en_US |
dc.language.iso | en | en_US |
dc.publisher | AME PUBL CO | en_US |
dc.subject | Non-alcoholic fatty liver disease (NAFLD) | en_US |
dc.subject | diabetes mellitus | en_US |
dc.subject | type 2 | en_US |
dc.subject | mac-2 binding protein glycan isomer | en_US |
dc.subject | liver fibrosis | en_US |
dc.title | Clinical implications of serum Mac-2-binding protein glycan isomer as a novel biomarker of advanced hepatic fibrosis in diabetes | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.21037/atm-20-5216 | - |
dc.relation.page | 1-12 | - |
dc.relation.journal | ANNALS OF TRANSLATIONAL MEDICINE | - |
dc.contributor.googleauthor | Park, Huiyul | - |
dc.contributor.googleauthor | Jun, Dae Won | - |
dc.contributor.googleauthor | Park, Hoon-Ki | - |
dc.contributor.googleauthor | Kim, Mimi | - |
dc.relation.code | 2020048311 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | bluefish01 | - |
dc.identifier.orcid | https://orcid.org/0000-0002-8266-0226 | - |
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