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dc.identifier.citationARTHRITIS CARE & RESEARCH, v. 72, no. 12, page. 1800-1808en_US
dc.description.abstractObjective: There is a paucity of data regarding health care costs associated with damage accrual in systemic lupus erythematosus. The present study was undertaken to describe costs associated with damage states across the disease course using multistate modeling. Methods: Patients from 33 centers in 11 countries were enrolled in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort within 15 months of diagnosis. Annual data on demographics, disease activity, damage (SLICC/American College of Rheumatology Damage Index [SDI]), hospitalizations, medications, dialysis, and selected procedures were collected. Ten-year cumulative costs (Canadian dollars) were estimated by multiplying annual costs associated with each SDI state by the expected state duration using a multistate model. Results: A total of 1,687 patients participated 88.7% were female, 49.0% were white, mean +/- SD age at diagnosis was 34.6 +/- 13.3 years, and mean time to follow-up was 8.9 years (range 0.6-18.5 years). Mean annual costs were higher for those with higher SDI scores as follows: $22,006 (Canadian) (95% confidence interval [95% CI] $16,662, $27,350) for SDI scores ˃= 5 versus $1,833 (95% CI $1,134, $2,532) for SDI scores of 0. Similarly, 10-year cumulative costs were higher for those with higher SDI scores at the beginning of the 10-year interval as follows: $189,073 (Canadian) (95% CI $142,318, $235,827) for SDI scores ˃= 5 versus $21,713 (95% CI $13,639, $29,788) for SDI scores of 0. Conclusion: Patients with the highest SDI scores incur 10-year cumulative costs that are ~9-fold higher than those with the lowest SDI scores. By estimating the damage trajectory and incorporating annual costs, data on damage can be used to estimate future costs, which is critical knowledge for evaluating the cost-effectiveness of novel therapies.en_US
dc.description.sponsorshipThe views expressed herein are those of the authors and not necessarily those of the National Health Service, the National Institute for Health Research, or the Department of Health. The Systemic Lupus International Collaborating Clinics research network received funding for this study from UCB Pharmaceuticals. The Montreal General Hospital Lupus Clinic is partially supported by the Singer Family Fund for Lupus Research. The Hopkins Lupus cohort is supported by the NIH (grants AR-43727 and AR-069572). Dr. Hanly’s work was supported by the CIHR (grant MOP-88526). Dr. Gordon’s work was supported by Lupus UK, Sandwell and West Birmingham Hospitals NHS Trust, and the NIHR/Wellcome Trust Clinical Research Facility in Birmingham. Dr. Bae’s work was supported by the Bio and Medical Technology Development Program of the National Research Foundation, funded by the Ministry of Science and ICT (grant NRF-2017M3A9B4050335). Drs. Isenberg and Rahman’s work was supported by the NIHR University College London Hospitals Biomedical Research Centre. Dr. Bruce’s work was funded by Arthritis Research UK, the NIHR Manchester Biomedical Research Unit, and the NIHR/Wellcome Trust Manchester Clinical Research Facility. Dr. Fortin’s work was supported by the Université Laval (Canada Research Chair on Systemic Autoimmune Rheumatic Diseases). Dr. Ramsey-Goldman’s work was supported by the NIH (grants 1U54-TR-001353 [formerly 8UL1-TR-000150 and UL1-RR-025741], K24-AR-02318, and P60-AR-064464 [formerly P60-AR-48098]). Dr. Manzi’s work was supported by the NIH (grants R01-AR-046588 and K24-AR-002213). Dr. Ruiz-Irastorza’s work was supported by the Department of Education, Universities, and Research of the Basque Government. Dr. Jacobsen’s work was supported by the Danish Rheumatism Association (grant A3865). Dr. Clarke’s work was supported by the University of Calgary (Arthritis Society Chair in Rheumatic Diseases).en_US
dc.titleEconomic Evaluation of Damage Accrual in an International Systemic Lupus Erythematosus Inception Cohort Using a Multistate Model Approachen_US
dc.relation.journalARTHRITIS CARE & RESEARCH-
dc.contributor.googleauthorBarber, Megan R. W.-
dc.contributor.googleauthorHanly, John G.-
dc.contributor.googleauthorSu, Li-
dc.contributor.googleauthorUrowitz, Murray B.-
dc.contributor.googleauthorSt. Pierre, Yvan-
dc.contributor.googleauthorRomero-Diaz, Juanita-
dc.contributor.googleauthorGordon, Caroline-
dc.contributor.googleauthorBae, Sang-Cheol-
dc.contributor.googleauthorBernatsky, Sasha-
dc.contributor.googleauthorWallace, Daniel J.-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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