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인후두 역류질환에서 양성자 펌프 억제제 치료가 삶의 질에 미치는 영향

Title
인후두 역류질환에서 양성자 펌프 억제제 치료가 삶의 질에 미치는 영향
Other Titles
Impact on Quality of Life after Treatment with Proton Pump Inhibitor in Laryngopharyngeal Reflux
Author
정진혁
Keywords
Laryngopharyngeal reflux; Laryngoscopy; Proton pump inhibitor; Quality of life
Issue Date
2020-11
Publisher
대한이비인후과학회
Citation
Korean Journal of Otorhinolaryngology- Head and Neck Surgery, v. 63, NO 11, Page. 517-522
Abstract
Background and Objectives Several studies have assessed the impact of laryngopharyngealreflux disease (LPRD) on the health-related quality of life (HR-QoL), showing significantimpairment of HR-QoL. This study aims to assess the impact of proton pump inhibitor (PPI)treatment of LPRDs to enhance HR-QoL. Subjects and Method We prospectively collected data from LPRD patients from April2017 to July 2019. Patients who have reflux symptom index (RSI) of ≥13 or reflux findingscore (RFS) of ≥7 were enrolled in this study. We assessed HR-QoL using a questionnairewith EORTC QLQ-H&N35, -C30 on the first visit. Patients were treated with PPI (Ilaprazole20 mg/day) on their visits at 4, 8, and 12 weeks. RSI and RFS were measured at each visit andHR-QoL was reevaluated on the last visit. Results Ninety-five patients completed the 3-months follow-up and were enrolled in thisstudy. Female : male ratio was 71:24 and the mean age was 57.0±11.9 (27-80). The initial RSIand RFS were 16.3±8.8 and 12.6±2.9, respectively, but were changed to 11.1±9.7 and 9.7±2.6(p˂0.001 in both) at 12 weeks after the treatment. Global health status/QoL, speech problem,dry mouth, and coughing were significantly improved. Conclusion PPI administration is effective in treating LPRD, where effects begin to appear at4 weeks after treatment. HR-QoL was also improved in patients who have RSI improvement.
URI
https://www.kjorl.org/journal/view.php?doi=10.3342/kjorl-hns.2019.00899https://repository.hanyang.ac.kr/handle/20.500.11754/172841
ISSN
2092-6529
DOI
10.3342/kjorl-hns.2019.00899
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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인후두 역류질환에서 양성자 펌프 억제제 치료가 삶의 질에 미치는 영향.pdfDownload
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