Relationship between the atlantodental interval and T1 slope after atlantoaxial fusion in patients with rheumatoid arthritis

Abstract

Background: Atlantoaxial fusion has been widely used for the treatment of atlantoaxial instability (AAI). However, atlantoaxial fusion sacrifces the motion of atlantoaxial articulation, and postoperative loss of cervical lordosis and aggravation of cervical kyphosis are observed. We investigated various factors under the hypothesis that the atlanto‑dental interval (ADI) and T1 slope may be associated with sagittal alignment after atlantoaxial fusion in patients with rheumatoid arthritis (RA). Methods: We retrospectively investigated 64 patients with RA who underwent atlantoaxial fusion due to AAI. Radio‑logical factors, including the ADI, T1 slope, Oc-C2 angle, cervical sagittal vertical axis, and C2–C7 angle, were measured before and after surgery. Results: The various factors associated with atlantoaxial fusion before and after surgery were compared accord‑ing to the upper and lower preoperative ADIs. There was a signifcant diference in the T1 slope 1 year after surgery(p=0.044) among the patients with lower preoperative ADI values. The multivariate logistic regression analysis showed that the preoperative ADI (>7.92 mm) defned in the receiver-operating characteristic curve analysis was an independent predictive factor for the increase in the T1 slope 1 year after atlantoaxial fusion (odds ratio, 4.59; 95% confdence interval, 1.34–15.73; p=0.015). Conclusion: We found an association between the preoperative ADI and diference in the T1 slope after atlantoaxial fusion in the patients with RA. A preoperative ADI (>7.92 mm) was an independent predictor for the increase in the T1 slope after atlantoaxial fusion. Therefore, performing surgical treatment when the ADI is low would lead to better cervical sagittal alignment.