Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김계성 | - |
dc.date.accessioned | 2022-08-29T07:31:24Z | - |
dc.date.available | 2022-08-29T07:31:24Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.citation | COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, v. 18, page. 3649-3665 | en_US |
dc.identifier.issn | 2001-0370 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S2001037020304931?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/172612 | - |
dc.description.abstract | CRISPR/Cas systems are popular genome editing tools that belong to a class of programmable nucleases and have enabled tremendous progress in the field of regenerative medicine. We here outline the structural and molecular frameworks of the well-characterized type II CRISPR system and several computational tools intended to facilitate experimental designs. The use of CRISPR tools to generate disease models has advanced research into the molecular aspects of disease conditions, including unraveling the molecular basis of immune rejection. Advances in regenerative medicine have been hindered by major histocompatibility complex-human leukocyte antigen (HLA) genes, which pose a major barrier to cell- or tissue-based transplantation. Based on progress in CRISPR, including in recent clinical trials, we hypothesize that the generation of universal donor immune-engineered stem cells is now a realistic approach to tackling a multitude of disease conditions. | en_US |
dc.description.sponsorship | We thank all the members of Suri's laboratory and Kye-Seong Kim's laboratory for their helpful insights. This work was supported by a grant from the National Research Foundation of Korea (NRF) (2017M3A9C6061361). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER | en_US |
dc.subject | CRISPR | en_US |
dc.subject | Cas9 | en_US |
dc.subject | HLA | en_US |
dc.subject | Disease models | en_US |
dc.subject | CAR T | en_US |
dc.title | Disease modeling and stem cell immunoengineering in regenerative medicine using CRISPR/Cas9 systems | en_US |
dc.type | Article | en_US |
dc.relation.volume | 18 | - |
dc.identifier.doi | 10.1016/j.csbj.2020.11.026 | - |
dc.relation.page | 3649-3665 | - |
dc.relation.journal | COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL | - |
dc.contributor.googleauthor | Antao, Ainsley Mike | - |
dc.contributor.googleauthor | Karapurkar, Janardhan Keshav | - |
dc.contributor.googleauthor | Lee, Dong Ryul | - |
dc.contributor.googleauthor | Kim, Kye-Seong | - |
dc.contributor.googleauthor | Ramakrishna, Suresh | - |
dc.relation.code | 2020049734 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOMEDICAL SCIENCE | - |
dc.identifier.pid | ks66kim | - |
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