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dc.contributor.author조항준-
dc.date.accessioned2022-08-16T02:33:28Z-
dc.date.available2022-08-16T02:33:28Z-
dc.date.issued2020-11-
dc.identifier.citationPHYSICS IN MEDICINE AND BIOLOGY, v. 65, NO 23, article no. 235024-235024en_US
dc.identifier.issn0031-9155-
dc.identifier.issn1361-6560-
dc.identifier.urihttps://iopscience.iop.org/article/10.1088/1361-6560/abb2ec-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/172430-
dc.description.abstractImproved gradient performance in an MRI system reduces distortion in echo planar imaging (EPI), which has been a key imaging method for functional studies. A lightweight, low-cryogen compact 3T MRI scanner (C3T) is capable of achieving 80 mT m(-1) gradient amplitude with 700 T m(-1) s(-1) slew rate, in comparison with a conventional whole-body 3T MRI scanner (WB3T, 50 mT m(-1) with 200 T m(-1) s(-1)). We investigated benefits of the high-performance gradients in a high-spatial-resolution (1.5 mm isotropic) functional MRI study. Reduced echo spacing in the EPI pulse sequence inherently leads to less severe geometric distortion, which provided higher accuracy than with WB3T for registration between EPI and anatomical images. The cortical coverage of C3T datasets was improved by more accurate signal depiction (i.e. less dropout or pile-up). Resting-state functional analysis results showed that greater magnitude and extent in functional connectivity (FC) for the C3T than the WB3T when the selected seed region is susceptible to distortions, while the FC matrix for well-known brain networks showed little difference between the two scanners. This shows that the improved quality in EPI is particularly valuable for studying certain brain regions typically obscured by severe distortion.en_US
dc.description.sponsorshipThe authors thank Drs Ek Tsoon Tan and Tom K Foo from GE Research Center for providing hyperband EPI pulse sequence and built-in-system reconstruction. This work was supported by National Institute of Biomedical Imaging and Bioengineering (NIBIB) at the National Institutes of Health (NIH) (Grant/Award Nos. U01 EB024450 and U01 EB026976). YS, JDT, and MAB acknowledge the following financial interest: Mayo Clinic has licensed IP related to the compact 3T to GE Healthcare.en_US
dc.language.isoenen_US
dc.publisherIOP PUBLISHING LTDen_US
dc.subjecthigh-performance gradientsen_US
dc.subjectcompact 3Ten_US
dc.subjectEPI distortionen_US
dc.subjectfMRIen_US
dc.subjectfunctional connectivityen_US
dc.titleThe benefit of high-performance gradients on echo planar imaging for BOLD-based resting-state functional MRIen_US
dc.typeArticleen_US
dc.relation.no23-
dc.relation.volume65-
dc.identifier.doi10.1088/1361-6560/abb2ec-
dc.relation.page235024-235024-
dc.relation.journalPHYSICS IN MEDICINE AND BIOLOGY-
dc.contributor.googleauthorKang, Daehun-
dc.contributor.googleauthorJo, Hang Joon-
dc.contributor.googleauthorIn, Myung-Ho-
dc.contributor.googleauthorYarach, Uten-
dc.contributor.googleauthorMeyer, Nolan K.-
dc.contributor.googleauthorBardwell Speltz, Lydia J.-
dc.contributor.googleauthorGray, Erin M.-
dc.contributor.googleauthorTrzasko, Joshua D.-
dc.contributor.googleauthorHuston, John, III-
dc.contributor.googleauthorBernstein, Matt A.-
dc.relation.code2020054694-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidhangjoonjo-
dc.identifier.orcidhttps://orcid.org/0000-0002-9180-3831-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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