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Evaluation and Management of Difficult-to-Treat and Severe Asthma: An Expert Opinion From the Korean Academy of Asthma, Allergy and Clinical Immunology, the Working Group on Severe Asthma

Title
Evaluation and Management of Difficult-to-Treat and Severe Asthma: An Expert Opinion From the Korean Academy of Asthma, Allergy and Clinical Immunology, the Working Group on Severe Asthma
Author
문지용
Keywords
Severe asthma; biologics; diagnosis; eosinophil; expert opinion; IgE; treatment; IL5; IL4
Issue Date
2020-11
Publisher
KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
Citation
ALLERGY, ASTHMA & IMMUNOLOGY RESEARCH, v. 12, no. 6, page. 910-933
Abstract
Severe asthma (SA) presents in about 3%-5% of adult asthmatics and is responsible for over 60% of asthma-related medical expenses, posing a heavy socioeconomic burden. However, to date, a precise definition of or clear diagnostic criteria for SA have not been established, and therefore, it has been challenging for clinicians to diagnose and treat this disease. Currently, novel biologics targeting several molecules, such as immunoglobulin E, interleukin (IL)5, and IL4/IL13, have emerged, and many new drugs are under development. These have brought a paradigm shift in understanding the mechanism of SA and have also provided new treatment options. However, we need to agree on a precise definition of and its diagnostic criteria for SA. Additionally, it is necessary to explain the diagnostic criteria and to summarize current standard and additional treatment options. This review is an experts' opinion on SA from the Korean Academy of Asthma, Allergy, and Clinical Immunology, the Working Group on Severe Asthma, and aims to provide a definition of and diagnostic criteria for SA, and propose future direction for SA diagnosis and management in Korea.
URI
https://e-aair.org/DOIx.php?id=10.4168/aair.2020.12.6.910https://repository.hanyang.ac.kr/handle/20.500.11754/172272
ISSN
2092-7355; 2092-7363
DOI
10.4168/aair.2020.12.6.910
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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