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Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression

Title
Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression
Author
최재훈
Keywords
GENE-EXPRESSION PROFILES;DENDRITIC CELLS;MECHANISMS;IDENTIFICATION;INFLAMMATION;PRECURSORS;DIVERSITY;DISEASE;BURDEN;ZBTB46
Issue Date
2020-10
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE IMMUNOLOGY, v. 21, no. 10, page. 1194-1204
Abstract
Williams and colleagues investigate the origin, dynamics and transcriptional profiles of aortic intima macrophages during atherosclerosis disease progression. Early atherosclerosis depends upon responses by immune cells resident in the intimal aortic wall. Specifically, the healthy intima is thought to be populated by vascular dendritic cells (DCs) that, during hypercholesterolemia, initiate atherosclerosis by being the first to accumulate cholesterol. Whether these cells remain key players in later stages of disease is unknown. Using murine lineage-tracing models and gene expression profiling, we reveal that myeloid cells present in the intima of the aortic arch are not DCs but instead specialized aortic intima resident macrophages (Mac(AIR)) that depend upon colony-stimulating factor 1 and are sustained by local proliferation. Although Mac(AIR)comprise the earliest foam cells in plaques, their proliferation during plaque progression is limited. After months of hypercholesterolemia, their presence in plaques is overtaken by recruited monocytes, which induce Mac(AIR)-defining genes. These data redefine the lineage of intimal phagocytes and suggest that proliferation is insufficient to sustain generations of macrophages during plaque progression.
URI
https://www.nature.com/articles/s41590-020-0768-4https://repository.hanyang.ac.kr/handle/20.500.11754/172041
ISSN
1529-2908; 1529-2916
DOI
10.1038/s41590-020-0768-4
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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