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3D printing of self-healing ferrogel prepared from glycol chitosan, oxidized hyaluronate, and iron oxide nanoparticles

Title
3D printing of self-healing ferrogel prepared from glycol chitosan, oxidized hyaluronate, and iron oxide nanoparticles
Author
이근용
Keywords
Self-healing; Ferrogel; Glycol chitosan; Oxidized hyaluronate; 3D printing
Issue Date
2020-10
Publisher
ELSEVIER SCI LTD
Citation
CARBOHYDRATE POLYMERS, v. 245, article no. 116496, page. 116496-116496
Abstract
Hydrogel systems that show self-healing ability after mechanical damage are receiving increasing attention. However, self-healing hydrogels suitable for biomedical applications are limited owing to complex preparation methods. Furthermore, few studies have demonstrated the self-healing property of ferrogels. In this study, we demonstrated that glycol chitosan (GC) and oxidized hyaluronate (OHA) can be used to form a self-healing ferrogel in the presence of superparamagnetic iron oxide nanoparticles (SPIONs) without additional chemical cross-linkers. The overall characteristics of GC/OHA/SPION ferrogel varied based on the GC/OHA ratio, SPION content, and total polymer concentration. Interestingly, GC/OHA/SPION ferrogel was used to fabricate 3D-printed constructs of various shapes via an extrusion printing method. These constructs were responsive to the magnetic field, suggesting their potential application in 4D printing. This approach to developing self-healing ferrogels with biocompatible polysaccharides may prove useful in designing and fabricating drug delivery sys-tems and tissue engineering scaffolds, via 3D printing.
URI
https://www.sciencedirect.com/science/article/pii/S0144861720306706?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/172022
ISSN
0144-8617; 1879-1344
DOI
10.1016/j.carbpol.2020.116496
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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