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dc.identifier.citationARTHRITIS & RHEUMATOLOGY, v. 72, no. 10, page. 1734-1740en_US
dc.description.abstractObjective. In previous studies, atherosclerotic vascular events (AVEs) were shown to occur in similar to 10% of patients with systemic lupus erythematosus (SLE). We undertook this study to investigate the annual occurrence and potential risk factors for AVEs in a multinational, multiethnic inception cohort of patients with SLE. Methods. A large 33-center cohort of SLE patients was followed up yearly between 1999 and 2017. AVEs were attributed to atherosclerosis based on SLE being inactive at the time of the AVE as well as typical atherosclerotic changes observed on imaging or pathology reports and/or evidence of atherosclerosis elsewhere. Analyses included descriptive statistics, rate of AVEs per 1,000 patient-years, and univariable and multivariable relative risk regression models. Results. Of the 1,848 patients enrolled in the cohort, 1,710 had ˃= 1 follow-up visit after enrollment, for a total of 13,666 patient-years. Of these 1,710 patients, 3.6% had ˃= 1 AVEs attributed to atherosclerosis, for an event rate of 4.6 per 1,000 patient-years. In multivariable analyses, lower AVE rates were associated with antimalarial treatment (hazard ratio [HR] 0.54 [95% confidence interval (95% CI) 0.32-0.91]), while higher AVE rates were associated with any prior vascular event (HR 4.00 [95% CI 1.55-10.30]) and a body mass index of ˃40 kg/m(2) (HR 2.74 [95% CI 1.04-7.18]). A prior AVE increased the risk of subsequent AVEs (HR 5.42 [95% CI 3.17-9.27], P˂ 0.001). Conclusion. The prevalence of AVEs and the rate of AVE accrual demonstrated in the present study is much lower than that seen in previously published data. This may be related to better control of both the disease activity and classic risk factors.en_US
dc.description.sponsorshipThe views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health.The Hopkins Lupus Cohort is supported by the NIH (grants AR-43727 and AR-69572). The Montreal General Hospital Lupus Clinic is supported in part by the Singer Family Fund for Lupus Research. Dr. Bae’s work was supported in part by the Ministry of Science & ICT of the Republic of Korea (grant NRF-2017M3A9B4050335). Dr. Fortin holds a tier 1 Canada Research Chair on Systemic Autoimmune Rheumatic Diseases at Université Laval. Dr. Clarke holds The Arthritis Society Chair in Rheumatic Diseases at the University of Calgary. Dr. Gordon’s work was supported by Lupus UK, the Sandwell and West Birmingham Hospitals NHS Trust, and the NIHR/Wellcome Trust Birmingham Clinical Research Facility. Dr. Hanly’s work was supported by the Canadian Institutes of Health Research (grant MOP-88526). Drs. Isenberg and Rahman’s work was supported by the NIHR and University College London Hospitals Biomedical Research Center. Dr. Bruce’s work was supported by the NIHR (Senior Investigator Award), Arthritis Research UK, the NIHR Manchester Biomedical Centre, and the NIHR/Wellcome Trust Manchester Clinical Research Facility. Dr. Dooley’s work was supported by the NIH (grant RR-00046). Dr. Ramsey-Goldman’s work was supported by the NIH (grants 5UL-1TR-001422-02 [formerly 8UL-1TR-000150], UL-1RR-025741, K24-AR-02318, and P60-AR-064464 [formerly P60-AR-48098]). Dr. Ruiz-Irastorza’s work was supported by the Department of Education, Universities, and Research of the Basque Government. Dr. Jacobsen’s work was supported by the Danish Rheumatism Association (grant A3865) and the Novo Nordisk Foundation (grant A05990).en_US
dc.titleAccrual of Atherosclerotic Vascular Events in a Multicenter Inception Systemic Lupus Erythematosus Cohorten_US
dc.relation.journalARTHRITIS & RHEUMATOLOGY-
dc.contributor.googleauthorUrowitz, Murray B.-
dc.contributor.googleauthorGladman, Dafna D.-
dc.contributor.googleauthorFarewell, Vernon-
dc.contributor.googleauthorSu, Jiandong-
dc.contributor.googleauthorJuanita, Romero-Diaz-
dc.contributor.googleauthorBae, Sang-Cheol-
dc.contributor.googleauthorFortin, Paul R.-
dc.contributor.googleauthorSanchez-Guerrero, Jorge-
dc.contributor.googleauthorClarke, Ann Elaine-
dc.contributor.googleauthorBernatsky, Sasha-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.orcidhttps://orcid.org/ 0000-0003-4658-1093-
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