Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 원은지 | - |
dc.date.accessioned | 2022-05-23T06:50:33Z | - |
dc.date.available | 2022-05-23T06:50:33Z | - |
dc.date.issued | 2022-02 | - |
dc.identifier.citation | In Marine Pollution Bulletin February 2022 175 | en_US |
dc.identifier.issn | 0025-326X | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0025326X22000789 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/171057 | - |
dc.description.abstract | The increased use of disinfectants due to the spread of the novel coronavirus infection (e.g. COVID-19) has caused burden in the environment but knowledge on its ecotoxicological impact on the estuary environment is limited. Here we report in vivo and molecular endpoints that we used to assess the effects of chloroxylenol (PCMX) and benzalkonium chloride (BAC), which are ingredients in liquid handwash, dish soap products, and sanitizers used by consumers and healthcare workers on the estuarine rotifer Brachionus koreanus. PCMX and BAC significantly affected the life table parameters of B. koreanus. These chemicals modulated the activities of antioxidant enzymes such as superoxide dismutase and catalase and increased reactive oxygen species even at low concentrations. Also, PCMX and BAC caused alterations in the swimming speed and rotation rate of B. koreanus. Furthermore, an RNA-seq-based ingenuity pathway analysis showed that PCMX affected several signaling pathways, allowing us to predict that a low concentration of PCMX will have deleterious effects on B. koreanus. The neurotoxic and mitochondrial dysfunction event scenario induced by PCMX reflects the underlying molecular mechanisms by which PCMX produces outcomes deleterious to aquatic organisms. | en_US |
dc.description.sponsorship | This work was supported by the Korea Environment Industry and Technology Institute (KEITI) through the Technology Development Project for Safety Management of Household Chemical Products Project, funded by the Ministry of Environment (MOE) of Korea (2020002970007, 1485017749), a grant of the National Research Foundation of Korea (2021R1C1C2005922) funded to Eun-Ji Won, a grant of the National Research Foundation of Korea (2020R11A1A01074607) funded to Young Hwan Lee, and a grant from the Development of Techniques for Assessment and Management of Hazardous Chemicals in the Marine Environment program of the Korean Ministry of Oceans and Fisheries (PE20010) to Jae-Seong Lee. | en_US |
dc.language.iso | en | en_US |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en_US |
dc.subject | Antimicrobials | en_US |
dc.subject | RNA sequencing | en_US |
dc.subject | Ingenuity pathway analysis | en_US |
dc.subject | Estuarine rotifer | en_US |
dc.subject | Brachionus koreanus | en_US |
dc.title | Molecular evidence for suppression of swimming behavior and reproduction in the estuarine rotifer Brachionus koreanus in response to COVID-19 disinfectants | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.marpolbul.2022.113396 | - |
dc.relation.journal | MARINE POLLUTION BULLETIN | - |
dc.contributor.googleauthor | Won, Eun-Ji | - |
dc.contributor.googleauthor | Byeon, Eunjin | - |
dc.contributor.googleauthor | Lee, Young Hwan | - |
dc.contributor.googleauthor | Jeong, Haksoo | - |
dc.contributor.googleauthor | Lee, Yoseop | - |
dc.contributor.googleauthor | Kim, Min-Sub | - |
dc.contributor.googleauthor | Jo, Hyeong-Wook | - |
dc.contributor.googleauthor | Moon, Joon-Kwan | - |
dc.contributor.googleauthor | Wang, Minghua | - |
dc.contributor.googleauthor | Lee, Jae-Seong | - |
dc.contributor.googleauthor | Shin, Kyung-Hoon | - |
dc.relation.code | 2022037524 | - |
dc.sector.campus | E | - |
dc.sector.daehak | OFFICE OF ACADEMIC AFFAIRS[E] | - |
dc.sector.department | CENTER FOR CREATIVE CONVERGENCE EDUCATION | - |
dc.identifier.pid | ejwon | - |
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