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Spatiotemporal dissociation of fMRI activity in the caudate nucleus underlies human de novo motor skill learning

Title
Spatiotemporal dissociation of fMRI activity in the caudate nucleus underlies human de novo motor skill learning
Author
김성신
Keywords
de novo motor skill learning; caudate nucleus; spatiotemporal dissociation; cortico-caudate interactions; fMRI
Issue Date
2020-09
Publisher
NATL ACAD SCIENCES
Citation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 117, no. 38, page. 23886-23897
Abstract
Motor skill learning involves a complex process of generating novel movement patterns guided by evaluative feedback, such as a reward. Previous literature has suggested anteroposteriorly separated circuits in the striatum to be implicated in early goal-directed and later automatic stages of motor skill learning, respectively. However, the involvement of these circuits has not been well elucidated in human de novo motor skill learning, which requires learning arbitrary action-outcome associations and value-based action selection. To investigate this issue, we conducted a human functional MRI (fMRI) experiment in which participants learned to control a computer cursor by manipulating their right fingers. We discovered a double dissociation of fMRI activity in the anterior and posterior caudate nucleus, which was associated with performance in the early and late learning stages. Moreover, cognitive and sensorimotor cortico-caudate interactions predicted individual learning performance. Our results suggest parallel corticocaudate networks operating in different stages of human de novo motor skill learning.
URI
https://www.pnas.org/doi/full/10.1073/pnas.2003963117https://repository.hanyang.ac.kr/handle/20.500.11754/170746
ISSN
0027-8424
DOI
10.1073/pnas.2003963117
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COLLEGE OF ENGINEERING[S](공과대학) > ETC
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