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Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila

Title
Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila
Author
남진우
Keywords
PROGENITOR MAINTENANCE; LYMPH-GLAND; HEMATOPOIETIC PROGENITORS; HEMOCYTE LINEAGES; IMMUNE-RESPONSE; STEM-CELLS; MODEL; PROLIFERATION; PHAGOCYTOSIS; SPECIFICATION
Issue Date
2020-09
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE COMMUNICATIONS, v. 11, no. 1, article no. 4483
Abstract
The Drosophila lymph gland, the larval hematopoietic organ comprised of prohemocytes and mature hemocytes, has been a valuable model for understanding mechanisms underlying hematopoiesis and immunity. Three types of mature hemocytes have been characterized in the lymph gland: plasmatocytes, lamellocytes, and crystal cells, which are analogous to vertebrate myeloid cells, yet molecular underpinnings of the lymph gland hemocytes have been less investigated. Here, we use single-cell RNA sequencing to comprehensively analyze heterogeneity of developing hemocytes in the lymph gland, and discover previously undescribed hemocyte types including adipohemocytes, stem-like prohemocytes, and intermediate prohemocytes. Additionally, we identify the developmental trajectory of hemocytes during normal development as well as the emergence of the lamellocyte lineage following active cellular immunity caused by wasp infestation. Finally, we establish similarities and differences between embryonically derived- and larval lymph gland hemocytes. Altogether, our study provides detailed insights into the hemocyte development and cellular immune responses at single-cell resolution.
URI
https://www.nature.com/articles/s41467-020-18135-yhttps://repository.hanyang.ac.kr/handle/20.500.11754/170731
ISSN
2041-1723
DOI
10.1038/s41467-020-18135-y
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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