Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김지은 | - |
dc.date.accessioned | 2022-05-06T01:35:34Z | - |
dc.date.available | 2022-05-06T01:35:34Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.citation | ANTIBIOTICS-BASEL, v. 9, no. 9, article no. 617 | en_US |
dc.identifier.issn | 2079-6382 | - |
dc.identifier.uri | https://www.mdpi.com/2079-6382/9/9/617 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/170606 | - |
dc.description.abstract | This study examined changes in the clinical characteristics of community-acquired acute pyelonephritis (CA-APN) in South Korea between the period 2010-2011 and 2017-2018. We recruited all CA-APN patients aged >= 19 years who visited eight hospitals in South Korea from September 2017 to August 2018, prospectively. Data collected were compared with those from the previous study in 2010-2012, with the same design and participation from 11 hospitals. A total of 617 patients were enrolled and compared to 818 patients' data collected in 2010-2011.Escherichia coliwas the most common causative pathogen of CA-APN in both periods (87.3% vs. 86.5%,p= 0.680).E. coliisolates showed significantly higher antimicrobial resistance against fluoroquinolone (32.0% vs. 21.6%,p< 0.001), cefotaxime (33.6% vs. 8.3%,p< 0.001), and trimethoprim/sulfamethoxazole (37.5% vs. 29.2%,p= 0.013) in 2017-2018 than in 2010-2011. Total duration of antibiotic treatment increased from 16.55 +/- 9.68 days in 2010-2011 to 19.12 +/- 9.90 days in 2017-2018 (p< 0.001); the duration of carbapenem usage increased from 0.59 +/- 2.87 days in 2010-2011 to 1.79 +/- 4.89 days in 2010-2011 (p< 0.001). The median hospitalization was higher for patients in 2017-2018 than in 2010-2011 (9 vs. 7 days,p< 0.001). In conclusion, antimicrobial resistance ofE. colito almost all antibiotic classes, especially third generation cephalosporin, increased significantly in CA-APN in South Korea. Consequently, total duration of antibiotic treatment, including carbapenem usage, increased. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) grant (Grant No.: NRF-2017R1C1B5017504) funded by the Ministry of Science and ICT, government of Korea; a grant from the Bio & Medical Technology Development Program of the National Research Foundation (NRF) and funded by the Korean government (MSIT) (Funding No. 2019M3E5D1A01066063). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.subject | pyelonephritis | en_US |
dc.subject | urinary tract infection | en_US |
dc.subject | antimicrobial resistance | en_US |
dc.subject | Korea | en_US |
dc.title | Changes in Clinical Characteristics of Community-Acquired Acute Pyelonephritis and Antimicrobial Resistance of Uropathogenic Escherichia coli in South Korea in the Past Decade | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.3390/antibiotics9090617 | - |
dc.relation.page | 1-12 | - |
dc.relation.journal | ANTIBIOTICS-BASEL | - |
dc.contributor.googleauthor | Kwon, Ki Tae | - |
dc.contributor.googleauthor | Kim, Bongyoung | - |
dc.contributor.googleauthor | Ryu, Seong-yeol | - |
dc.contributor.googleauthor | Wie, Seong-Heon | - |
dc.contributor.googleauthor | Kim, Jieun | - |
dc.contributor.googleauthor | Jo, Hyun-uk | - |
dc.contributor.googleauthor | Park, Se Yoon | - |
dc.contributor.googleauthor | Hong, Kyung-Wook | - |
dc.contributor.googleauthor | Kim, Hye In | - |
dc.contributor.googleauthor | Kim, Hyun Ah | - |
dc.relation.code | 2020047123 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | quidam76 | - |
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