Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김현성 | - |
dc.date.accessioned | 2022-05-02T01:21:03Z | - |
dc.date.available | 2022-05-02T01:21:03Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.citation | LABORATORY INVESTIGATION, v. 101, no. 2, page. 155-164 | en_US |
dc.identifier.issn | 0023-6837 | - |
dc.identifier.issn | 1530-0307 | - |
dc.identifier.uri | https://www.nature.com/articles/s41374-020-00496-z | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/170467 | - |
dc.description.abstract | Lung cancer is an aggressive disease and the leading cause of cancer-related deaths worldwide. In the past several decades, the incidence of adenocarcinoma has significantly increased, and accounts for similar to 40% of all lung cancer cases. In the present study, we investigated the clinicopathologic significance of microRNA-130b (miR-130b) in lung adenocarcinoma and analyzed its cancer-specific functions. RNA was extracted from formalin-fixed paraffin-embedded specimens of 146 lung adenocarcinoma cases, and miR-130b expression was analyzed using quantitative real-time polymerase chain reaction. NCI-H1650 cells were transfected with miR-130b mimic and inhibitor to determine its effects on tumor cell proliferation, migration, and invasion. The expression of miR-130b in lung adenocarcinoma tissues was classified into two groups according to the median value. High expression of miR-130b was associated with higher histological grade, advanced pathologic T stage, lymph node metastasis, and lymphovascular invasion. Moreover, survival analysis showed that high miR-130b expression was significantly associated with unfavorable prognosis. In addition, miR-130b upregulation promoted cell migration and invasion, while its downregulation resulted in decreased cell proliferation, migration, and wound healing in in vitro experiments. In conclusion, these findings suggest that miR-130b promotes tumor progression and serves as a biomarker of poor prognosis for patients with lung adenocarcinoma. Hence, targeting miR-130b may serve as a potential therapeutic strategy for lung cancer. | en_US |
dc.description.sponsorship | This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1D1A1B07048798). We would like to thank Sungwoong Kim, Jeongyun Eom, and Jisook Kim (Department of Pathology, Hanyang University Hospital) for their technical assistance. | en_US |
dc.language.iso | en | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | ACTIVATED RECEPTOR-GAMMA | en_US |
dc.subject | CELL-PROLIFERATION | en_US |
dc.subject | TUMOR-SUPPRESSOR | en_US |
dc.subject | CANCER CELLS | en_US |
dc.subject | MIR-130B | en_US |
dc.subject | INVASION | en_US |
dc.subject | EXPRESSION | en_US |
dc.subject | MIGRATION | en_US |
dc.subject | THERAPY | en_US |
dc.subject | GLIOMA | en_US |
dc.title | MicroRNA-130b functions as an oncogene and is a predictive marker of poor prognosis in lung adenocarcinoma | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/s41374-020-00496-z | - |
dc.relation.journal | LABORATORY INVESTIGATION | - |
dc.contributor.googleauthor | Kim, Yeseul | - |
dc.contributor.googleauthor | Kim, Hyunsung | - |
dc.contributor.googleauthor | Bang, Seongsik | - |
dc.contributor.googleauthor | Jee, Seungyun | - |
dc.contributor.googleauthor | Jang, Kiseok | - |
dc.relation.code | 2020050991 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hhnt5841 | - |
dc.identifier.orcid | https://orcid.org/0000-0002-8935-7414 | - |
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