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Exosomes derived from chemically induced human hepatic progenitors inhibit oxidative stress induced cell death

Title
Exosomes derived from chemically induced human hepatic progenitors inhibit oxidative stress induced cell death
Author
황경균
Keywords
antioxidant activity; cell survival; exosome therapy; human hepatic progenitor cells-derived exosome (EXOhCdHs); liver disease
Issue Date
2020-09
Publisher
WILEY
Citation
BIOTECHNOLOGY AND BIOENGINEERING, v. 117, no. 9, page. 2658-2667
Abstract
The emerging field of regenerative medicine has revealed that the exosome contributes to many aspects of development and disease through intercellular communication between donor and recipient cells. However, the biological functions of exosomes secreted from cells have remained largely unexplored. Here, we report that the human hepatic progenitor cells (CdHs)-derived exosome (EXOhCdHs) plays a crucial role in maintaining cell viability. The inhibition of exosome secretion treatment with GW4869 results in the acceleration of reactive oxygen species (ROS) production, thereby causing a decrease of cell viability. This event provokes inhibition of caspase dependent cell death signaling, leading to a ROS-dependent cell damage response and thus induces promotion of antioxidant gene expression or repair of cell death of hypoxia-exposed cells. Together, these findings show the effect of exosomes in regeneration of liver cells, and offer valuable new insights into liver regeneration.
URI
https://onlinelibrary.wiley.com/doi/10.1002/bit.27447https://repository.hanyang.ac.kr/handle/20.500.11754/170380
ISSN
0006-3592; 1097-0290
DOI
10.1002/bit.27447
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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