Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 민경환 | - |
dc.date.accessioned | 2022-04-26T07:53:46Z | - |
dc.date.available | 2022-04-26T07:53:46Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.citation | APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, v. 28, no. 7, page. 544-550 | en_US |
dc.identifier.issn | 1541-2016 | - |
dc.identifier.issn | 1533-4058 | - |
dc.identifier.uri | https://journals.lww.com/appliedimmunohist/Fulltext/2020/08000/Expression_of_UTX_Indicates_Poor_Prognosis_in.10.aspx | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/170309 | - |
dc.description.abstract | Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX) is involved in the epigenetic regulation. A previous mouse xenograft study revealed that UTX knockdown is associated with downregulated expression of matrix metalloproteinase-11 (MMP-11). The authors investigated 224 cases of breast cancer from Kangbuk Samsung Medical Center between 2000 and 2005. Nuclear UTX and cytoplasmic MMP-11 expressions were assessed using immunohistochemistry of tumor tissue microarray specimens. The relationships between the expression of UTX, MMP-11, and patients' outcomes were analyzed. UTX expression was significantly associated with high histologic grade, lymphatic invasion, vascular invasion, and tumoral expression of MMP-11. Survival analysis revealed that patients with UTX expression had a poorer overall survival rate (P=0.010) as well as diminished disease-free survival rate (P=0.001). The prognostic power of UTX expression was significant in patients with luminal-type breast cancer (P=0.027, overall survival;P=0.008, disease-free survival). Validation of UTX can provide further prognostic information beyond traditional indicators and represents a potential therapeutic target for breast cancer. | en_US |
dc.description.sponsorship | Supported by the research fund of Hanyang University (HY-2019). | en_US |
dc.language.iso | en | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | en_US |
dc.subject | breast cancer | en_US |
dc.subject | UTX | en_US |
dc.subject | MMP-11 | en_US |
dc.subject | prognosis | en_US |
dc.subject | molecular classification | en_US |
dc.title | Expression of UTX Indicates Poor Prognosis in Patients With Luminal Breast Cancer and is Associated With MMP-11 Expression | en_US |
dc.type | Article | en_US |
dc.relation.no | 7 | - |
dc.relation.volume | 28 | - |
dc.identifier.doi | 10.1097/PAI.0000000000000795 | - |
dc.relation.page | 544-550 | - |
dc.relation.journal | APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | - |
dc.contributor.googleauthor | Kim, Gi Jeong | - |
dc.contributor.googleauthor | Kim, Dong-Hoon | - |
dc.contributor.googleauthor | Min, Kyueng-Whan | - |
dc.contributor.googleauthor | Chae, Seoung Wan | - |
dc.contributor.googleauthor | Kim, Se Hoon | - |
dc.contributor.googleauthor | Son, Byoung Kwan | - |
dc.contributor.googleauthor | Moon, Kyoung Min | - |
dc.contributor.googleauthor | Kim, Young Hwan | - |
dc.relation.code | 2020045973 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kyueng | - |
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