155 0

Expression of UTX Indicates Poor Prognosis in Patients With Luminal Breast Cancer and is Associated With MMP-11 Expression

Title
Expression of UTX Indicates Poor Prognosis in Patients With Luminal Breast Cancer and is Associated With MMP-11 Expression
Author
민경환
Keywords
breast cancer; UTX; MMP-11; prognosis; molecular classification
Issue Date
2020-08
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, v. 28, no. 7, page. 544-550
Abstract
Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX) is involved in the epigenetic regulation. A previous mouse xenograft study revealed that UTX knockdown is associated with downregulated expression of matrix metalloproteinase-11 (MMP-11). The authors investigated 224 cases of breast cancer from Kangbuk Samsung Medical Center between 2000 and 2005. Nuclear UTX and cytoplasmic MMP-11 expressions were assessed using immunohistochemistry of tumor tissue microarray specimens. The relationships between the expression of UTX, MMP-11, and patients' outcomes were analyzed. UTX expression was significantly associated with high histologic grade, lymphatic invasion, vascular invasion, and tumoral expression of MMP-11. Survival analysis revealed that patients with UTX expression had a poorer overall survival rate (P=0.010) as well as diminished disease-free survival rate (P=0.001). The prognostic power of UTX expression was significant in patients with luminal-type breast cancer (P=0.027, overall survival;P=0.008, disease-free survival). Validation of UTX can provide further prognostic information beyond traditional indicators and represents a potential therapeutic target for breast cancer.
URI
https://journals.lww.com/appliedimmunohist/Fulltext/2020/08000/Expression_of_UTX_Indicates_Poor_Prognosis_in.10.aspxhttps://repository.hanyang.ac.kr/handle/20.500.11754/170309
ISSN
1541-2016; 1533-4058
DOI
10.1097/PAI.0000000000000795
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE