T-Cell-Mimicking Nanoparticles for Cancer Immunotherapy
- Title
- T-Cell-Mimicking Nanoparticles for Cancer Immunotherapy
- Author
- 최제민
- Keywords
- cancer; cell-mimicking nanoparticles; cytotoxic T-lymphocytes; immunotherapy; nanomedicine
- Issue Date
- 2020-08
- Publisher
- WILEY-V C H VERLAG GMBH
- Citation
- ADVANCED MATERIALS, v. 32, no. 39, article no. 2003368
- Abstract
- Cancer immunotherapies, including adoptive T cell transfer and immune checkpoint blockades, have recently shown considerable success in cancer treatment. Nevertheless, transferred T cells often become exhausted because of the immunosuppressive tumor microenvironment. Immune checkpoint blockades, in contrast, can reinvigorate the exhausted T cells; however, the therapeutic efficacy is modest in 70-80% of patients. To address some of the challenges faced by the current cancer treatments, here T-cell-membrane-coated nanoparticles (TCMNPs) are developed for cancer immunotherapy. Similar to cytotoxic T cells, TCMNPs can be targeted at tumors via T-cell-membrane-originated proteins and kill cancer cells by releasing anticancer molecules and inducing Fas-ligand-mediated apoptosis. Unlike cytotoxic T cells, TCMNPs are resistant to immunosuppressive molecules (e.g., transforming growth factor-beta 1 (TGF-beta 1)) and programmed death-ligand 1 (PD-L1) of cancer cells by scavenging TGF-beta 1 and PD-L1. Indeed, TCMNPs exhibit higher therapeutic efficacy than an immune checkpoint blockade in melanoma treatment. Furthermore, the anti-tumoral actions of TCMNPs are also demonstrated in the treatment of lung cancer in an antigen-nonspecific manner. Taken together, TCMNPs have a potential to improve the current cancer immunotherapy.
- URI
- https://onlinelibrary.wiley.com/doi/10.1002/adma.202003368https://repository.hanyang.ac.kr/handle/20.500.11754/170017
- ISSN
- 0935-9648; 1521-4095
- DOI
- 10.1002/adma.202003368
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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