Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김용태 | - |
dc.date.accessioned | 2022-03-30T05:30:58Z | - |
dc.date.available | 2022-03-30T05:30:58Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.citation | INVESTIGATIVE AND CLINICAL UROLOGY, v. 61, no. 4, page. 441-451 | en_US |
dc.identifier.issn | 2466-0493 | - |
dc.identifier.issn | 2466-054X | - |
dc.identifier.uri | https://icurology.org/DOIx.php?id=10.4111/icu.2020.61.4.441 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/169544 | - |
dc.description.abstract | Purpose: Despite the role of carbon monoxide in ameliorating ischemia-reperfusion injury (IRI), its use in the clinical setting is restricted owing to its toxicity. Herein, we investigated the in vivo effects of carbon monoxide-releasing molecule-3 (CORM-3) on IRI. Materials and Methods: Fifteen rats were equally and randomly divided into three groups: sham (right nephrectomy), control (right nephrectomy and left renal ischemia), and CORM-3 (right nephrectomy and CORM-3 injection before left renal ischemia). Kidney tissues and blood samples collected from sacrificed rats were evaluated to determine the renoprotective effect and mechanism of CORM-3. Results: Concentrations of serum creatinine and kidney injury molecule-1 in the CORM-3 group were significantly lower than in the control group after 75 minutes of IRI (1.2 vs. 2.4 mg/dL, p=0.01, and 292 vs. 550 pg/mL, p<0.001, respectively). Furthermore, the CORM-3 group exhibited a higher portion of normal tubules and glomeruli. TUNEL staining revealed fewer apoptotic renal tubular cells in the CORM-3 group than in the control group. The expression of 960 genes in the CORM-3 group was also altered. Pretreatment with CORM-3 before renal IRI produced a significant renoprotective effect. Fifteen of the altered genes were found to be involved in the peroxisome proliferator-activated receptors signaling pathway, and the difference in the expression of these genes between the CORM-3 and control groups was statistically significant (p<0.001). Conclusions: CORM-3 ameliorates IRI by decreasing apoptosis and may be a novel strategy for protection against renal warm IRI. | en_US |
dc.description.sponsorship | This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2017R1C1B5018097). We thank A Ra Jung for contributing animal surgery and technical assistance. This manuscript was selected as the best paper at the 71st Korean Urological Association meeting in 2019. | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN UROLOGICAL ASSOC | en_US |
dc.subject | Carbon monoxide | en_US |
dc.subject | Ischemia | en_US |
dc.subject | Kidney diseases | en_US |
dc.title | Carbon monoxide–releasing molecule-3: Amelioration of renal ischemia reperfusion injury in a rat model | en_US |
dc.type | Article | en_US |
dc.relation.volume | 61 | - |
dc.identifier.doi | 10.4111/icu.2020.61.4.441 | - |
dc.relation.page | 441-451 | - |
dc.relation.journal | INVESTIGATIVE AND CLINICAL UROLOGY | - |
dc.contributor.googleauthor | Kim, Dae Keun | - |
dc.contributor.googleauthor | Shin, Su-Jin | - |
dc.contributor.googleauthor | Lee, Jiyoung | - |
dc.contributor.googleauthor | Park, Sung Yul | - |
dc.contributor.googleauthor | Kim, Yong Tae | - |
dc.contributor.googleauthor | Choi, Hong Yong | - |
dc.contributor.googleauthor | Yoon, Young Eun | - |
dc.contributor.googleauthor | Moon, Hong Sang | - |
dc.relation.code | 2020052620 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | ytkimuro | - |
dc.identifier.orcid | https://orcid.org/0000-0002-7646-2098 | - |
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