121 28

Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning

Title
Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning
Author
최재훈
Keywords
MICE; MACROPHAGES; CELLS; TRANSPLANTATION; EOSINOPHILS; ADIPOCYTES; MECHANISMS; INJECTION; DISEASE; MOUSE
Issue Date
2020-07
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v. 10, no. 1, article no. 12001
Abstract
Brown adipose tissue generates heat via the mitochondrial uncoupling protein UCP1 to protect against obesity and hypothermia. Fas mutant MRL/lpr mice exhibit a significantly leaner phenotype compared to wild type MRL/MpJ mice. In this study, we evaluated the inflammatory cell population in the adipose tissue of MRL/lpr mice, which could potentially influence their lean phenotype. Furthermore, we compared beige fat activity between the MRL/MpJ and MRL/lpr mice. Fas mutation resulted in high body temperature, improved glucose tolerance, and decreased fat mass and adipocyte size. Fas mutation prevented high-fat diet-induced obesity and decreased the white adipose tissue M1:M2 ratio. When mice were fed a high-fat diet, UCP1, IL-4, IL-10, and tyrosine hydroxylase genes had significantly higher expression in Fas-mutant mice than in wild type mice. After a cold challenge, UCP1 expression and browning were also significantly higher in the Fas-mutant mice. In summary, Fas-mutant mice are resistant to high-fat diet-induced obesity due to increased IL-4 and IL-10 levels and the promotion of thermogenic protein activity and browning in their adipose tissues. STAT6 activation might contribute to M2 polarisation by increasing IL-4 and IL-10 levels while increases in M2 and tyrosine hydroxylase levels promote browning in response to Fas mutation.
URI
https://www.nature.com/articles/s41598-020-68971-7https://repository.hanyang.ac.kr/handle/20.500.11754/169285
ISSN
2045-2322
DOI
10.1038/s41598-020-68971-7
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
Files in This Item:
Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE