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L-Cysteine-Meditated Self-Assembled PtRu Derived Bimetallic Metal–Carbon Hybrid: An Excellent Peroxidase Mimics for Colorimetric and Fluorometric Detection of Hydrogen Peroxide and Cholesterol

Title
L-Cysteine-Meditated Self-Assembled PtRu Derived Bimetallic Metal–Carbon Hybrid: An Excellent Peroxidase Mimics for Colorimetric and Fluorometric Detection of Hydrogen Peroxide and Cholesterol
Author
성기훈
Keywords
bimetallic materials; cholesterol detection; enzyme mimics; hybrid structure; H2O2 detection
Issue Date
2021-12
Publisher
WILEY
Citation
ADVANCED MATERIALS INTERFACES; NOV 10 2021, p2101115 16p.
Abstract
Artificial enzymes have attracted considerable attention because of their significant advantages over natural enzymes. Herein, the authors report a simple hydrothermal strategy for producing a bimetallic metal — N-, S-doped carbon (NS-C@PtRu) hybrid derived from L-cysteine-mediated self-assembly of PtRu. The peroxidase-like activity and colloidal stability of the NS-C@PtRu are tuned by varying the amount of L-cysteine, the source material for the N-, S-doped carbon. The NS-C@PtRu exhibits good dispersibility, synergistic interactions (metal–metal, metal–carbon), non-metal (N, S) doping, more catalytic active sites, improved noble metallic catalyst performance, and high utilization efficiency. As an excellent peroxidase mimic, NS-C@PtRu catalyzes the oxidation of 3,3′,5′,5′-tetramethylbenzidine (TMB), and Amplex Red (AR) substrates, producing colorimetric and fluorometric signals that offer efficient detection of H2O2. Furthermore, colorimetric and fluorometric cholesterol detection is proposed by combining cholesterol oxidase-catalyzed cholesterol oxidation with NS-C@PtRu-catalyzed TMB/AR oxidation. The fluorometric cholesterol sensor exhibited a lower limit of detection of 1.4 μmol L−1 and rapid response, whereas the colorimetric sensor exhibited a wide detection range of 0.1–6 mmol L−1and colorimetric changes that can be seen with the naked eyes. Both sensing methods demonstrated excellent selectivity and recovery in determining cholesterol in spiked human serum samples.
URI
https://onlinelibrary.wiley.com/doi/full/10.1002/admi.202101115https://repository.hanyang.ac.kr/handle/20.500.11754/169222
ISSN
21967350
DOI
10.1002/admi.202101115
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > BIONANO ENGINEERING(생명나노공학과) > Articles
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