Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박희호 | - |
dc.date.accessioned | 2022-03-17T07:52:49Z | - |
dc.date.available | 2022-03-17T07:52:49Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.citation | SCIENCE ADVANCES, v. 6, no. 31, article no. eabc1564 | en_US |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | https://www.science.org/doi/10.1126/sciadv.abc1564 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/169165 | - |
dc.description.abstract | The outbreak of the highly contagious and deadly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19), has posed a serious threat to public health across the globe, calling for the development of effective diagnostic markers and therapeutics. Here, we report a highly reliable severity diagnostic biomarker, acetylated 676th lysine transforming growth factor-beta-induced protein (TGFBIp K676Ac). TGFBIp K676Ac was consistently elevated in the blood of patients with SARS-CoV-2 pneumonia (n = 113), especially in patients in the intensive care unit (ICU) compared to non-ICU patients. Patients' blood samples showed increased cytokines and lymphopenia, which are exemplary indicators of SARS-CoV-2 pneumonia. Treatment with TGFBIp neutralizing antibodies suppressed the cytokine storm. The increased level of TGFBIp K676Ac in ICU patients suggests the promise of this protein as a reliable severity diagnostic biomarker for severe SARS-CoV-2 disease. | en_US |
dc.description.sponsorship | This work was supported by a grant from the National Research Foundation of Korea (NRF) funded by the Korean Government (MSIT) (grant no. 2018R1A2A3075013 and 2020R1A2C1004131) and the Ministry of Education (NRF-2018R1D1A1B07050422). This study was supported by KIST Institutional Program (2V07950). This research was also supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (grant no. HI15C0001). | en_US |
dc.language.iso | en | en_US |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | en_US |
dc.subject | CYTOKINE STORM | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | ACTIVATION | en_US |
dc.subject | PROTEIN | en_US |
dc.title | Acetylated K676 TGFBIp as a severity diagnostic blood biomarker for SARS-CoV-2 pneumonia | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1126/sciadv.abc1564 | - |
dc.relation.journal | SCIENCE ADVANCES | - |
dc.contributor.googleauthor | Park, Hee Ho | - |
dc.contributor.googleauthor | Kim, Hong Nam | - |
dc.contributor.googleauthor | Kim, Hyelim | - |
dc.contributor.googleauthor | Yoo, Youngbum | - |
dc.contributor.googleauthor | Shin, Hyosoo | - |
dc.contributor.googleauthor | Choi, Eun Young | - |
dc.contributor.googleauthor | Bae, Jong-Sup | - |
dc.contributor.googleauthor | Lee, Wonhwa | - |
dc.relation.code | 2020054717 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | parkhh | - |
dc.identifier.orcid | https://orcid.org/0000-0003-1498-5624 | - |
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