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Determination of Serotonin Concentration in Single Human Platelets through Single-Entity Electrochemistry

Title
Determination of Serotonin Concentration in Single Human Platelets through Single-Entity Electrochemistry
Author
장진호
Keywords
serotonin biosensor; platelet serotonin; human platelet detection; ultramicroelectrode; single-entity electrochemistry
Issue Date
2020-06
Publisher
AMER CHEMICAL SOC
Citation
ACS SENSORS, v. 5, no. 7, page. 1943-1948
Abstract
This research introduces a method to directly detect serotonin in a single platelet through single-entity electrochemistry. Platelets isolated from human blood were analyzed by cyclic voltammetry and current time measurements. When a single platelet collides with an ultrarnicroelectrode, serotonin inside the platelet is oxidized at the electrode surface, and an anodic current peak is consequently observed during measurement. The concentration of serotonin can be determined by integrating this peak current. In addition, this method can be used to determine the platelet concentration. Analysis of the collision frequency of platelets can provide information about the platelet concentration in the blood. Asa result, platelet levels and serotonin concentrations in single platelets can be measured quickly sand easily.
URI
https://pubs.acs.org/doi/10.1021/acssensors.0c00267https://repository.hanyang.ac.kr/handle/20.500.11754/168830
ISSN
2379-3694
DOI
10.1021/acssensors.0c00267
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
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