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Deciphering Macrophage Phenotypes upon Lipid Uptake and Atherosclerosis

Title
Deciphering Macrophage Phenotypes upon Lipid Uptake and Atherosclerosis
Author
최재훈
Keywords
Atherosclerosis; Macrophage; Lipid uptake; In vivo model; In vitro model
Issue Date
2020-06
Publisher
KOREA ASSOC IMMUNOLOGISTS
Citation
IMMUNE NETWORK, v. 20, no. 3, page. 1-21
Abstract
In the progression of atherosclerosis, macrophages are the key immune cells for foam cell formation. During hyperlipidemic condition, phagocytic cells such as monocytes and macrophages uptake oxidized low-density lipoproteins (oxLDLs) accumulated in subintimal space, and lipid droplets are accumulated in their cytosols. In this review, we discussed the characteristics and phenotypic changes of macrophages in atherosclerosis and the effect of cytosolic lipid accumulation on macrophage phenotype. Due to macrophage plasticity, the inflammatory phenotypes triggered by oxLDL can be re-programmed by cytosolic lipid accumulation, showing downregulation of NF-kappa B activation followed by activation of anti-inflammatory genes, leading to tissue repair and homeostasis. We also discuss about various in vivo and in vitro models for atherosclerosis research and next generation sequencing technologies for foam cell gene expression profiling. Analysis of the phenotypic changes of macrophages during the progression of atherosclerosis with adequate approach may lead to exact understandings of the cellular mechanisms and hint therapeutic targets for the treatment of atherosclerosis.
URI
https://immunenetwork.org/DOIx.php?id=10.4110/in.2020.20.e22https://repository.hanyang.ac.kr/handle/20.500.11754/167376
ISSN
1598-2629; 2092-6685
DOI
10.4110/in.2020.20.e22
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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