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Sensitive detection of DMSO/DMF in water, human urine and blood plasma using novel 1,8-naphthalimide-based amphiphilic spectroscopic probes

Title
Sensitive detection of DMSO/DMF in water, human urine and blood plasma using novel 1,8-naphthalimide-based amphiphilic spectroscopic probes
Author
채필석
Issue Date
2021-04
Publisher
ELSEVIER SCI LTD
Citation
DYES AND PIGMENTS, v. 189, Article no. 109240, 12pp
Abstract
Dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) are industrial toxins that need to be sensed. We synthesized 1,8-naphthalimide-m-benzenesulfonamide (NBS)-bearing probes (1–5) with different pendant chains for sensitive detection of DMSO and DMF. These probes exhibited aggregation-induced emission enhancement with increasing water concentration in ethanol. Among these, monopod probes with a single NBS unit (1–4) selectively showed large fluorescence quenching upon addition of DMSO/DMF in water. Based on this result, we prepared two water-soluble probes (8 and 9) bearing the NBS unit. These probes displayed enhanced sensitivity in detecting DMSO/DMF in water compared to probe 1, showing an extraordinary low LOD of 0.0025% for DMSO and DMF detection in water. Probe 9 was similarly effective at sensitively sensing DMSO/DMF when tap or lake water was used as the medium, and the LOD of this probe was 0.05% when biological fluids such as diluted human urine and blood plasma were used instead of water. According to DLS, FE-SEM and zeta potential studies as well as DFT calculations, disaggregation of probe aggregates and electron transfer from the photo-excited probe to DMSO/DMF are likely both responsible for the high selectivity and sensitivity of this probe in detecting the organic solvents containing a sulfoxide/amide group.
URI
https://www.sciencedirect.com/science/article/pii/S014372082100108Xhttps://repository.hanyang.ac.kr/handle/20.500.11754/166814
ISSN
0143-7208
DOI
10.1016/j.dyepig.2021.109240
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > BIONANO ENGINEERING(생명나노공학과) > Articles
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