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dc.contributor.author장진호-
dc.date.accessioned2021-12-06T06:40:08Z-
dc.date.available2021-12-06T06:40:08Z-
dc.date.issued2020-05-
dc.identifier.citationANALYTICAL CHEMISTRY, v. 92, no. 12, page. 8159-8169en_US
dc.identifier.issn0003-2700-
dc.identifier.issn1520-6882-
dc.identifier.urihttps://pubs.acs.org/doi/10.1021/acs.analchem.0c00275-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/166718-
dc.description.abstractA unique surface-enhanced Raman scattering (SERS) measurement scheme to discriminate gall bladder (GB) polyp and GB cancer by analysis of bile juice is proposed. Along with the high sensitivity of SERS, external voltage application during SERS measurement was incorporated to improve sample discriminability. For this purpose, Au nanodendrites were constructed on a screen-printed electrode (referred to as AuND@SPE), and Raman spectra of extracted aqueous phases from raw bile juice samples were acquired using the AuND@SPE at voltages from -300 to 300 mV. The sample spectra resembled that of bilirubin, possessing an open chain tetrapyrrole, showing that bilirubin derivatives in bile juice were mainly responsible for the observed peaks. Discrimination of GB polyp and GB cancer using just the normal SERS spectra was not achieved but became apparent when the spectra were acquired at a voltage of -100 mV. When voltage-applied SERS spectra of bilirubin and urobilinogen (one of bilirubin's derivatives) were examined, a sudden intensity elevation occurring at -100 mV was observed for urobilinogen but not bilirubin. Based on examination of corresponding cyclic voltammograms, the potential-driven strong adsorption of urobilinogen (no faradaic charge transfer) on AuND occurring at -100 mV induced a substantial increase in SERS intensity. It was presumed that the content of urobilinogen in the bile juice of a GB cancer patient would be higher than that of a GB polyp patient, and the contained urobilinogen was sensitively highlighted by applying -100 mV during SERS measurement, allowing clear discrimination of GB cancer against GB polyp.en_US
dc.description.sponsorshipThis research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, & Future Planning (NRF-2018R1A2B2002662).en_US
dc.language.isoenen_US
dc.publisherAMER CHEMICAL SOCen_US
dc.subjectRAMAN-SPECTROSCOPYen_US
dc.subjectINFRARED-SPECTROSCOPYen_US
dc.subjectBILIRUBINen_US
dc.subjectUROBILINOGENen_US
dc.subjectGALLBLADDERen_US
dc.subjectURINEen_US
dc.subjectCARCINOMAen_US
dc.subjectPANCREASen_US
dc.subjectDISEASEen_US
dc.subjectBLOODen_US
dc.titleFeasibility of Voltage-Applied SERS Measurement of Bile Juice as an Effective Analytical Scheme to Enhance Discrimination between Gall Bladder (GB) Polyp and GB Canceren_US
dc.typeArticleen_US
dc.relation.no12-
dc.relation.volume92-
dc.identifier.doi10.1021/acs.analchem.0c00275-
dc.relation.page8159-8169-
dc.relation.journalANALYTICAL CHEMISTRY-
dc.contributor.googleauthorVu, Tung Duy-
dc.contributor.googleauthorJang, Eunjin-
dc.contributor.googleauthorLee, Jihye-
dc.contributor.googleauthorChoi, Dongho-
dc.contributor.googleauthorChang, Jinho-
dc.contributor.googleauthorChung, Hoeil-
dc.relation.code2020048062-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF CHEMISTRY-
dc.identifier.pidjhcechem-
dc.identifier.researcherIDAAV-3344-2020-
dc.identifier.orcidhttps://orcid.org/0000-0002-5572-2364-
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COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
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