Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 손장원 | - |
dc.date.accessioned | 2021-11-01T01:55:05Z | - |
dc.date.available | 2021-11-01T01:55:05Z | - |
dc.date.issued | 2020-04 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v. 10, no. 1, article no. 6462 | en_US |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.nature.com/articles/s41598-020-63156-8 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/166075 | - |
dc.description.abstract | Poor adherence to medication can lead to treatment failure in healthcare workers (HWCs) with latent tuberculosis infection (LTBI) who are at high risk of developing active tuberculosis. However, the factors associated with non-completion of nine-month LTBI treatment with isoniazid (9H) have not been well studied. We investigated the completion rate and factors affecting adherence to LTBI treatment with 9H among HCWs. A prospective cohort study of 114 HCWs who were diagnosed with LTBI by QuantiFERON-TB Gold In-Tube tests were performed in a single university hospital between June 2016 and December 2017. All patients received the 9H LTBI treatment. At each visit, treatment adherence and development of adverse reactions to isoniazid were evaluated via a standard questionnaire. To evaluate the impact of the severity of hepatotoxicity on non-completion of LTBI treatment, we classified hepatotoxicity into two groups: severe hepatotoxicity was defined as alanine aminotransferase ˃3.0 times the upper normal limit (UNL) with symptoms or =5.0 times the UNL. Mild hepatotoxicity was defined as alanine aminotransferase˃UNL, but not meet the definition of severe hepatotoxicity. Overall, 71 HCWs (62.3%) completed LTBI treatment with 9H while 43 HCWs (37.7%) discontinued their treatment. Most discontinuation (81.4%, 35/43) occurred during the first three months of treatment. There were no significant differences in age, sex, occupation, or comorbidities between the HCWs who completed and those who discontinued LTBI treatment. However, HCWs who discontinued LTBI treatment had more hepatotoxicity than those who completed treatment (44.2% vs. 11.3%, P˂0.001). Cox proportional hazard analysis revealed that hepatotoxicity is the only factor significantly associated with discontinuation of 9H LTBI treatment (unadjusted HR=2.89, 95% CI=1.62-5.46). In multivariable analysis, not only severe hepatotoxicity (adjusted HR=7.99, 95% CI=3.05-20.94) but also mild hepatotoxicity was significantly associated with discontinuation of LTBI treatment (adjusted HR=2.34, 95% CI=1.05-5.21). The completion rate of 9H LTBI treatment was 62.3% among HCWs. While age, sex, occupation, and pretreatment comorbidities were not associated with treatment completion, isoniazid-induced hepatotoxicity significantly affected adherence. | en_US |
dc.description.sponsorship | This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1D1A1B03035267) and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI15C1543). | en_US |
dc.language.iso | en | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | ADVERSE EVENTS | en_US |
dc.subject | PREVALENCE | en_US |
dc.subject | RIFAMPIN | en_US |
dc.subject | RISK | en_US |
dc.title | Adherence to nine-month isoniazid for latent tuberculosis infection in healthcare workers: a prospective study in a tertiary hospital | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 10 | - |
dc.identifier.doi | 10.1038/s41598-020-63156-8 | - |
dc.relation.page | 6462-6469 | - |
dc.relation.journal | SCIENTIFIC REPORTS | - |
dc.contributor.googleauthor | Chung, Sung Jun | - |
dc.contributor.googleauthor | Lee, Hyun | - |
dc.contributor.googleauthor | Koo, Gun Woo | - |
dc.contributor.googleauthor | Min, Ji-Hee | - |
dc.contributor.googleauthor | Yeo, Yoomi | - |
dc.contributor.googleauthor | Park, Dong Won | - |
dc.contributor.googleauthor | Park, Tai Sun | - |
dc.contributor.googleauthor | Moon, Ji-Yong | - |
dc.contributor.googleauthor | Kim, Sang-Heon | - |
dc.contributor.googleauthor | Sohn, Jang Won | - |
dc.relation.code | 2020051242 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jwsohn | - |
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