Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2021-10-29T05:35:13Z | - |
dc.date.available | 2021-10-29T05:35:13Z | - |
dc.date.issued | 2020-04 | - |
dc.identifier.citation | ARTHRITIS & RHEUMATOLOGY, v. 72, no. 4, page. 658-666 | en_US |
dc.identifier.issn | 2326-5191 | - |
dc.identifier.issn | 2326-5205 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1002/art.41144 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/166058 | - |
dc.description.abstract | Objective The Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) has been shown to predict mortality, but its association with other important outcomes is unknown. We examined the association of baseline SLICC FI values with damage accrual in the SLICC inception cohort. Methods The baseline visit was defined as the first visit at which both organ damage (SLICC/American College of Rheumatology Damage Index [SDI]) and health-related quality of life (Short Form 36) were assessed. Baseline SLICC FI scores were calculated. Damage accrual was measured by the increase in SDI between the baseline assessment and the last study visit. Multivariable negative binomial regression was used to estimate the association between baseline SLICC FI values and the rate of increase in the SDI during follow-up, adjusting for relevant demographic and clinical characteristics. Results The 1,549 systemic lupus erythematosus (SLE) patients eligible for this analysis were mostly female (88.7%) with a mean +/- SD age of 35.7 +/- 13.3 years and a median disease duration of 1.2 years (interquartile range 0.9-1.5 years) at baseline. The mean +/- SD baseline SLICC FI was 0.17 +/- 0.08. Over a mean +/- SD follow-up of 7.2 +/- 3.7 years, 653 patients (42.2%) had an increase in SDI. Higher baseline SLICC FI values (per 0.05 increase) were associated with higher rates of increase in the SDI during follow-up (incidence rate ratio [IRR] 1.19 [95% confidence interval 1.13-1.25]), after adjusting for age, sex, ethnicity/region, education, baseline SLE Disease Activity Index 2000, baseline SDI, and baseline use of glucocorticoids, antimalarials, and immunosuppressive agents. Conclusion Our findings indicate that the SLICC FI predicts damage accrual in incident SLE, which further supports the SLICC FI as a valid health measure in SLE. | en_US |
dc.description.sponsorship | Supported by the Canadian Institutes of Health Research (grant MOP-88526). The Hopkins Lupus Cohort is supported by the NIH (grants AR-43727 and AR-69572). The Montreal General Hospital Lupus Clinic is supported in part by the Singer Family Fund for Lupus Research. Dr. Rockwood's work was supported by the Dalhousie Medical Research Foundation, the Canadian Institutes of Health Research, the QEII Health Sciences Centre Foundation (Foundation Family Innovation Fund), and the Capital Health Research Fund. Dr. Bae's work was supported in part by the Ministry of Science & ICT of the Republic of Korea (grant NRF-2017M3A9B4050335). Dr. Gordon's work was supported by Lupus UK, the Sandwell and West Birmingham Hospitals NHS Trust, and the NIHR/Wellcome Trust Birmingham Clinical Research Facility. Dr. Clarke's work was supported by the University of Calgary and the Arthritis Society. Dr. Fortin's work was supported by Universite Laval and the Arthritis Society. Dr. Bruce's work was supported by Arthritis Research UK, the NIHR Manchester Biomedical Centre, and the NIHR/Wellcome Trust Manchester Clinical Research Facility. Drs. Isenberg and Rahman's work was supported by the NIHR University College London Hospitals Biomedical Research Center. Dr. Dooley's work was supported by the NIH (grant RR-00046). Dr. RamseyGoldman's work was supported by the NIH (grants 5UL-1TR-001422-02 [formerly 8UL-1TR-000150], UL-1RR-025741, K24-AR-02318, and P60-AR-064464 [formerly P60-AR-48098]). Dr. Ruiz-Irastorza's work was supported by the Department of Education, Universities, and Research of the Basque Government. Dr. Jacobsen's was supported by the Danish Rheumatism Association (grant A3865) and the Novo Nordisk Foundation (grant A05990). | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY | en_US |
dc.subject | DEFICIT ACCUMULATION | en_US |
dc.subject | NEUROPSYCHIATRIC EVENTS | en_US |
dc.subject | RELATIVE FITNESS | en_US |
dc.subject | DISEASE-ACTIVITY | en_US |
dc.subject | MORTALITY | en_US |
dc.subject | PEOPLE | en_US |
dc.subject | TIME | en_US |
dc.subject | SURVIVAL | en_US |
dc.subject | LIFE | en_US |
dc.title | Prediction of Damage Accrual in Systemic Lupus Erythematosus Using the Systemic Lupus International Collaborating Clinics Frailty Index | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 72 | - |
dc.identifier.doi | 10.1002/art.41144 | - |
dc.relation.page | 658-666 | - |
dc.relation.journal | ARTHRITIS & RHEUMATOLOGY | - |
dc.contributor.googleauthor | Legge, Alexandra | - |
dc.contributor.googleauthor | Kirkland, Susan | - |
dc.contributor.googleauthor | Rockwood, Kenneth | - |
dc.contributor.googleauthor | Andreou, Pantelis | - |
dc.contributor.googleauthor | Bae, Sang-Cheol | - |
dc.contributor.googleauthor | Gordon, Caroline | - |
dc.contributor.googleauthor | Romero-Diaz, Juanita | - |
dc.contributor.googleauthor | Sanchez-Guerrero, Jorge | - |
dc.contributor.googleauthor | Wallace, Daniel J. | - |
dc.contributor.googleauthor | Bernatsky, Sasha | - |
dc.relation.code | 2020052915 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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