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On-site fabrication of injectable I-131-labeled microgels for local radiotherapy

Title
On-site fabrication of injectable I-131-labeled microgels for local radiotherapy
Author
최성용
Keywords
Injectable drug delivery system; Radiotherapy; Hyaluronic acid; 131I; Hydrogel microparticle
Issue Date
2020-04
Publisher
ELSEVIER
Citation
JOURNAL OF CONTROLLED RELEASE, v. 322, page. 337-345
Abstract
Nuclear medicine is a routine but essential clinical option for diagnostic imaging and disease treatment. Encapsulating radioisotopes in injectable biodegradable hydrogels is ideal for localizing radiation sources to target tissues or organs to achieve long-term, low-dose radiotherapy. However, difficulties in the on-site production of radioactive gels upon treatment and the unpredictable radiation level at the target region are major obstacles to their clinical use. In this study, we bypassed these limitations by developing locally injectable hydrogel microparticles based on I-131-labeled photo-crosslinkable hyaluronic acid (HA) and a microfluidic highthroughput droplet generator. This approach enabled rapid on-site production of injectable, radioactive, biodegradable (IRB) HA microgels, thus allowing their immediate therapeutic application with improved local retention and predictable radioactivity. We demonstrated the clinical utility of this comprehensive approach by preparing IRB HA microgels within 15 min and localizing them to the target tissue (rat muscle) with minimal offtarget biodistribution and in vivo radioactivity that extended beyond 3 weeks.
URI
https://www.sciencedirect.com/science/article/pii/S016836592030198X?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/165934
ISSN
0168-3659; 1873-4995
DOI
10.1016/j.jconrel.2020.03.046
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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