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dc.contributor.author정승준-
dc.date.accessioned2021-10-28T00:24:16Z-
dc.date.available2021-10-28T00:24:16Z-
dc.date.issued2020-04-
dc.identifier.citationJOURNAL OF INVESTIGATIVE DERMATOLOGY, v. 140, no. 11, Page. 2221-2221en_US
dc.identifier.issn0022-202X-
dc.identifier.issn1523-1747-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0022202X20313725?via%3Dihub-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/165827-
dc.description.abstractPsoriasis is an inflammatory skin disease associated with itch, which is a troublesome symptom with a few therapeutic options. TRPC4 is highly expressed in dorsal root ganglia (DRGs). Recently, we have revealed itch signaling in DRG neurons by which TRPC4 mediates itch to serotonergic antidepressants and demonstrated the antipruritic effect of the TRPC4 inhibitor ML204. However, the role of TRPC4 in acute and chronic itch is still largely unknown. Here, we have characterized the expression of TRPC4 in peptidergic DRG neurons and showed that acute itch induced by serotonin and histamine was attenuated in Trpc4-knockout mice and ML204-treated mice. We have also shown that silencing TRPC4 in DRG and its inhibition by intradermal injections were also effective in decreasing psoriatic itch after the repeated application of imiquimod, which is a preclinical model of psoriasis. Of clinical relevance, intradermal injections of ML204 in psoriasiform skin significantly reversed imiquimod-established chronic itch and cutaneous inflammation. Given that TRPC4 is expressed in human DRGs and a specific inhibitor is in clinical trials, our data not only expand our understanding of itch and psoriasis, but also reveal TRPC4 as a potential therapeutic target with considerable translational benefits.en_US
dc.description.sponsorshipWe acknowledge the National Psoriasis Foundation for funding this research through a Discovery Grant Award to TB. This research was also partially supported by a grant from the National Research Foundation of Korea to SJJ. (2019R1A2B5B01070643). The Trpc4 KO mice were kindly provided by D.E. Clapham.en_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.subjectPRURITUSen_US
dc.subjectRESPONSESen_US
dc.subjectPATHOGENESISen_US
dc.subjectRECEPTORen_US
dc.subjectDISEASEen_US
dc.subjectPOTENTen_US
dc.subjectMODELen_US
dc.subjectPAINen_US
dc.titleSensory Neuron-Expressed TRPC4 Is a Target for the Relief of Psoriasiform Itch and Skin Inflammation in Miceen_US
dc.typeArticleen_US
dc.relation.no11-
dc.relation.volume140-
dc.identifier.doi10.1016/j.jid.2020.03.959-
dc.relation.page2221-2221-
dc.relation.journalJOURNAL OF INVESTIGATIVE DERMATOLOGY-
dc.contributor.googleauthorLee, Sang Hoon-
dc.contributor.googleauthorTonello, Raquel-
dc.contributor.googleauthorChoi, Youngin-
dc.contributor.googleauthorJung, Sung Jun-
dc.contributor.googleauthorBerta, Temugin-
dc.relation.code2020048165-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pideurijj-
dc.identifier.orcidhttp://orcid.org/0000-0002-1051-6495-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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