Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김승현 | - |
dc.date.accessioned | 2021-10-27T06:56:26Z | - |
dc.date.available | 2021-10-27T06:56:26Z | - |
dc.date.issued | 2020-04 | - |
dc.identifier.citation | NEUROLOGY, v. 94, no. 15, page. E1657-E1663 | en_US |
dc.identifier.issn | 0028-3878 | - |
dc.identifier.issn | 1526-632X | - |
dc.identifier.uri | https://n.neurology.org/content/94/15/e1657 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/165814 | - |
dc.description.abstract | Objective To establish whether amyotrophic lateral sclerosis (ALS) is a multistep process in South Korean and Japanese populations when compared to Australian cohorts. Methods We generated incident data by age and sex for Japanese (collected between April 2009 and March 2010) and South Korean patients with ALS (collected between January 2011 and December 2015). Mortality rates were provided for Australian patients with ALS (collected between 2007 and 2016). We regressed the log of age-specific incidence against the log of age with least squares regression for each ALS population. Results We identified 11,834 cases of ALS from the 3 populations, including 6,524 Australian, 2,264 Japanese, and 3,049 South Korean ALS cases. We established a linear relation between the log incidence and log age in the 3 populations: Australia r(2) = 0.99, Japan r(2) = 0.99, South Korea r(2) = 0.99. The estimate slopes were similar across the 3 populations, being 5.4 (95% confidence interval [CI], 4.8-5.5) in Japanese, 5.4 (95% CI, 5.2-5.7) in Australian, and 4.4 (95% CI, 4.2-4.8) in South Korean patients. Conclusions The linear relationship between log age and log incidence is consistent with a multistage model of disease, with slope estimated suggesting that 6 steps were required in Japanese and Australian patients with ALS while 5 steps were needed in South Korean patients. Identification of these steps could identify novel therapeutic strategies. | en_US |
dc.description.sponsorship | This study was supported by research grants from the Motor Neuron Disease Research Institute of Australia, National Health and Medical Research Council of Australia (project grant numbers 510233, 1024915, 1055778), and the Brain Research Program of the National Research Foundation (NRF) funded by the Korean Ministry of Science & ICT (NRF-2018M3C7A1056512). This work was also supported by funding to Forefront, a collaborative research group dedicated to the study of frontotemporal dementia and motor neuron disease, from the National Health and Medical Research Council of Australia (program grant #1037746). | en_US |
dc.language.iso | en | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | en_US |
dc.subject | AMYOTROPHIC-LATERAL-SCLEROSIS | en_US |
dc.title | ALS is a multistep process in South Korean, Japanese, and Australian patients | en_US |
dc.type | Article | en_US |
dc.relation.no | 15 | - |
dc.relation.volume | 94 | - |
dc.identifier.doi | 10.1212/WNL.0000000000009015 | - |
dc.relation.page | 1657-1663 | - |
dc.relation.journal | NEUROLOGY | - |
dc.contributor.googleauthor | Vucic, Steve | - |
dc.contributor.googleauthor | Higashihara, Mana | - |
dc.contributor.googleauthor | Sobue, Gen | - |
dc.contributor.googleauthor | Atsuta, Naoki | - |
dc.contributor.googleauthor | Doi, Yuriko | - |
dc.contributor.googleauthor | Kuwabara, Satoshi | - |
dc.contributor.googleauthor | Kim, Seung Hyun | - |
dc.contributor.googleauthor | Kim, Inah | - |
dc.contributor.googleauthor | Oh, Ki-Wook | - |
dc.contributor.googleauthor | Park, Jinseok | - |
dc.relation.code | 2020048700 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kimsh1 | - |
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