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The Role of Deubiquitinating Enzymes in Hematopoiesis and Hematological Malignancies

Title
The Role of Deubiquitinating Enzymes in Hematopoiesis and Hematological Malignancies
Author
김계성
Keywords
DUBs; HSCs; myeloid; erythroid; leukemia; lymphoma; cell differentiation
Issue Date
2020-04
Publisher
MDPI
Citation
CANCERS, v. 12, no. 5, article no. 1103
Abstract
Hematopoietic stem cells (HSCs) are responsible for the production of blood cells throughout the human lifespan. Single HSCs can give rise to at least eight distinct blood-cell lineages. Together, hematopoiesis, erythropoiesis, and angiogenesis coordinate several biological processes, i.e., cellular interactions during development and proliferation, guided migration, lineage programming, and reprogramming by transcription factors. Any dysregulation of these processes can result in hematological disorders and/or malignancies. Several studies of the molecular mechanisms governing HSC maintenance have demonstrated that protein regulation by the ubiquitin proteasomal pathway is crucial for normal HSC function. Recent studies have shown that reversal of ubiquitination by deubiquitinating enzymes (DUBs) plays an equally important role in hematopoiesis; however, information regarding the biological function of DUBs is limited. In this review, we focus on recent discoveries about the physiological roles of DUBs in hematopoiesis, erythropoiesis, and angiogenesis and discuss the DUBs associated with common hematological disorders and malignancies, which are potential therapeutic drug targets.
URI
https://www.mdpi.com/2072-6694/12/5/1103https://repository.hanyang.ac.kr/handle/20.500.11754/165688
ISSN
2072-6694
DOI
10.3390/cancers12051103
Appears in Collections:
GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > BIOMEDICAL SCIENCE(의생명과학과) > Articles
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