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dc.contributor.author윤호주-
dc.date.accessioned2021-09-28T01:24:07Z-
dc.date.available2021-09-28T01:24:07Z-
dc.date.issued2020-04-
dc.identifier.citationTOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, v. 250, no. 4, page. 243-251en_US
dc.identifier.issn0040-8727-
dc.identifier.issn1349-3329-
dc.identifier.urihttps://www.jstage.jst.go.jp/article/tjem/250/4/250_243/_article-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/165347-
dc.description.abstractPneumonia is one of the most common causes of hospital admissions and mortality, and it is responsible for significant socioeconomic burden worldwide. Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa protein; which is involved in iron trafficking and has chemostatic and bacteriostatic effects. NGAL is also known as an early marker of many inflammatory diseases. However, little is known about the role of NGAL in the management of pneumonia. Thus, this study aimed to investigate whether plasma NGAL levels can predict intensive care unit (ICU) admission and in-hospital mortality in patients with pneumonia. This retrospective observational study included 241 adults hospitalized with pneumonia who underwent NGAL measurement. We compared the prognostic values of plasma NGAL with pneumonia severity index (PSI) for prediction of ICU admission and in-hospital mortality. Of 241 patients, 47 (19.5%) died during hospital admission. There was no significant difference between NGAL and PSI for predicting ICU admission (area under the receiver operating characteristic curve [AUC] of log NGAL vs. PSI, P > 0.999). Although log NGAL was useful in predicting in-hospital mortality, its ability was inferior to that of PSI (AUC of log NGAL vs. PSI, P = 0.008). Multivariable analysis revealed that log NGAL was significantly associated with ICU admission (adjusted odds ratio = 10.76, P < 0.001) and in-hospital mortality (adjusted odds ratio = 5.04, P = 0.004). These results suggest that plasma NGAL level is a useful biomarker for predicting ICU admission and mortality in hospitalized patients with pneumonia.en_US
dc.description.sponsorshipThis research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI19CO218) and the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (No. 2019M3E5D1A01069363).en_US
dc.language.isoenen_US
dc.publisherTOHOKU UNIV MEDICAL PRESSen_US
dc.subjectbiomarkeren_US
dc.subjectdeathen_US
dc.subjectintensive care unitsen_US
dc.subjectlipocalin-2en_US
dc.subjectpneumoniaen_US
dc.titleNeutrophil Gelatinase-Associated Lipocalin for Predicting Intensive Care Unit Admission and Mortality in Patients with Pneumoniaen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume250-
dc.identifier.doi10.1620/tjem.250.243-
dc.relation.page243-251-
dc.relation.journalTOHOKU JOURNAL OF EXPERIMENTAL MEDICINE-
dc.contributor.googleauthorMin, Ji-Hee-
dc.contributor.googleauthorLee, Hyun-
dc.contributor.googleauthorChung, Sung Jun-
dc.contributor.googleauthorYeo, Yoomi-
dc.contributor.googleauthorPark, Tai Sun-
dc.contributor.googleauthorPark, Dong Won-
dc.contributor.googleauthorMoon, Ji-Yong-
dc.contributor.googleauthorKim, Sang-Heon-
dc.contributor.googleauthorKim, Tae Hyung-
dc.contributor.googleauthorYoon, Ho Joo-
dc.relation.code2020052677-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidhjyoon-


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