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dc.contributor.author이승환-
dc.date.accessioned2021-09-28T00:48:55Z-
dc.date.available2021-09-28T00:48:55Z-
dc.date.issued2020-11-
dc.identifier.citationBIOSENSORS & BIOELECTRONICS, v. 167, Article no. 112514, 12ppen_US
dc.identifier.issn0956-5663-
dc.identifier.issn1873-4235-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0956566320305066?via%3Dihub-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/165261-
dc.description.abstractCurrent techniques for Gram-typing and for diagnosing a pathogen at the early infection stage rely on Gram stains, cultures, Enzyme linked immunosorbent assay (ELISA), polymerase chain reaction (PCR), and gene microarrays, which are labor-intensive and time-consuming approaches. In addition, a delayed or imprecise diagnosis of clinical pathogenic bacteria leads to a life-threatening emergency or overuse of antibiotics and a high-rate occurrence of antimicrobial-resistance microbes. Herein, we report high-performance antibiotics (as bioprobes) conjugated graphene micropattern field-effect transistors (ABX-GMFETs) to facilitate on-site Gram-typing and help in the detection of the presence or absence of Gram-negative and -positive bacteria in the samples. The ABX-GMFET platform, which consists of recognition probes and GM transistors conjugated with novel interfacing chemical compounds, was integrated into the microfluidics to minimize the required human intervention and facilitate automation. The mechanism of binding of ABX-GMFET was based on a charge or chemical moiety interaction between the bioprobes and target bacteria. Subsequently, ABX-GMFETs exhibited unprecedented high sensitivity with a limit of detection (LOD) of 100 CFU/mL (1–9 CFU/mL), real-time target specificity.en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER ADVANCED TECHNOLOGYen_US
dc.subjectPortable biosensoren_US
dc.subjectGraphene field-effect transistoren_US
dc.subjectInterfacing chemistryen_US
dc.subjectMicrofluidicsen_US
dc.subjectReal-time monitoringen_US
dc.subjectBioprobesen_US
dc.titleHigh-performance portable graphene field-effect transistor device for detecting Gram-positive and -negative bacteriaen_US
dc.typeArticleen_US
dc.relation.volume167-
dc.identifier.doi10.1016/j.bios.2020.112514-
dc.relation.page112514-112514-
dc.relation.journalBIOSENSORS & BIOELECTRONICS-
dc.contributor.googleauthorKim, Kyung Ho-
dc.contributor.googleauthorPark, Seon Joo-
dc.contributor.googleauthorPark, Chul Soon-
dc.contributor.googleauthorSeo, Sung Eun-
dc.contributor.googleauthorLee, Jiyeon-
dc.contributor.googleauthorKim, Jinyeong-
dc.contributor.googleauthorLee, Soohyun-
dc.contributor.googleauthorKim, Jun-Seob-
dc.contributor.googleauthorRyu, Choong-Min-
dc.contributor.googleauthorYong, Dongeun-
dc.contributor.googleauthorYoon, Hyeonseok-
dc.contributor.googleauthorSong, Hyun Seok-
dc.contributor.googleauthorLee, Sang Hun-
dc.contributor.googleauthorKwon, Oh Seok-
dc.contributor.googleauthorLee, Seung Hwan-
dc.relation.code2020051760-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF ENGINEERING SCIENCES[E]-
dc.sector.departmentDEPARTMENT OF BIONANO ENGINEERING-
dc.identifier.pidvincero78-
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > BIONANO ENGINEERING(생명나노공학과) > Articles
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