Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 양승 | - |
dc.date.accessioned | 2021-09-28T00:20:50Z | - |
dc.date.available | 2021-09-28T00:20:50Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | Annals of Pediatric Endocrinology & Metabolism, v. 25, no. 1, page. 31-37 | en_US |
dc.identifier.issn | 2287-1012 | - |
dc.identifier.issn | 2287-1292 | - |
dc.identifier.uri | https://e-apem.org/journal/view.php?doi=10.6065/apem.2020.25.1.31 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/165172 | - |
dc.description.abstract | Purpose: This study evaluated the -202 A/C insulin-like growth factor binding protein 3 (IGFBP-3) promoter polymorphism as a predictor of serum IGFBP-3 concentration and growth velocity after recombinant growth hormone (rhGH) therapy in patients with idiopathic short stature (ISS). Methods: Genotyping and serial measurement of clinical parameters were performed in 69 children with a confirmed diagnosis of ISS. Restriction fragment length polymorphism analysis was performed to determine the genotype at the -202 IGFBP-3 locus. Serum insulin-like growth factor 1 (IGF-1) and IGFBP-3 levels were measured at baseline and after 1 year of rhGH treatment, as were height standard deviation score and growth velocity. Results: The -202 A/C IGFBP-3 genotype comprised 69.6% AA, 24.6% AC, and 5.8% CC. One year of treatment did not produce a meaningful difference in IGF-1 or IGFBP-3 levels between children in the AA group and those with at least one copy of the C allele (AC/CC group). Comparing the 2 groups after one year also revealed no significant difference in growth velocity (ΔHeight: 9.061±1.612 cm/yr in the AA group, 9.421±1.864 in the AC/CC group, P=0.419). Conclusions: rhGH treatment was effective and there were no significant differences in IGF-1, IGFBP-3, or growth velocity according to genotype. Thus, -202 IGFBP-3 genotype may not be a major factor affecting individual growth responses in Korean children with ISS. | en_US |
dc.description.sponsorship | This study was financially supported by a research grant from the Investigator-Initiated Trials program of Dong-A ST Co., LTD. Opinions expressed in this paper are those of the authors and do not represent those of Dong-A ST Co., LTD. The authors would also like to thank Dong-A ST Co., LTD for supporting this research. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Korean society of pediatric endocrinology | en_US |
dc.subject | Insulin-like growth factor binding protein 3 | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | Idiopathic short stature | en_US |
dc.subject | Growth hormone | en_US |
dc.title | Effect of -202 A/C IGFBP-3 polymorphisms on growth responses in children with idiopathic short stature | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.6065/apem.2020.25.1.31 | - |
dc.relation.journal | Annals of Pediatric Endocrinology and Metabolism | - |
dc.contributor.googleauthor | Kang, Hye Ree | - |
dc.contributor.googleauthor | Hwang, Il Tae | - |
dc.contributor.googleauthor | Yang, Seung | - |
dc.relation.code | 2020001536 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jxisfriend | - |
dc.identifier.orcid | https://orcid.org/0000-0002-3380-6962 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.