50 0

Severe vitamin D deficiency is associated with emphysema progression in male patients with COPD

Title
Severe vitamin D deficiency is associated with emphysema progression in male patients with COPD
Author
문지용
Keywords
Chronic obstructive pulmonary disease; Emphysema; Vitamin D
Issue Date
2020-03
Publisher
W B SAUNDERS CO LTD
Citation
RESPIRATORY MEDICINE, v. 163, article no. 105890
Abstract
Background: Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of vitamin D deficiency. Vitamin D levels also correlate with lung function in patients with COPD. However, there are few reports on vitamin D deficiency and emphysema severity in COPD. This study aimed to investigate the effects of plasma 25-hydroxyvitamin D (25-OHD) level on emphysema severity in male COPD patients. Methods: A total of 151 male subjects were selected from the Korean Obstructive Lung Disease (KOLD) cohort. Subjects were subdivided into four subgroups according to their baseline plasma 25-OHD level: sufficiency (˃= 20 ng/ml), mild deficiency (15-20 ng/ml), moderate deficiency (10-15 ng/ml), and severe deficiency (˂10 ng/ml). Results: Baseline computed tomography (CT) emphysema indices revealed significant differences among the subgroups (p = 0.034). A statistically significant difference was also observed among the subgroups regarding change in the CT emphysema index over 3 years (p = 0.047). The annual increase in emphysema index was more prominent in the severe deficiency group (1.34% per year) than in the other groups (0.41% per year) (p = 0.003). Conclusions: This study demonstrates that CT emphysema indices were different among the four subgroups and supports that severe vitamin D deficiency is associated with rapid progression of emphysema in male patients with COPD.
URI
https://www.sciencedirect.com/science/article/pii/S0954611120300305?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/165137
ISSN
0954-6111; 1532-3064
DOI
10.1016/j.rmed.2020.105890
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE