Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안병규 | - |
dc.date.accessioned | 2021-09-08T00:39:42Z | - |
dc.date.available | 2021-09-08T00:39:42Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | PATHOLOGY RESEARCH AND PRACTICE, v. 216, no. 3, article no. 152821 | en_US |
dc.identifier.issn | 0344-0338 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0344033819321120?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/164942 | - |
dc.description.abstract | This study aimed to investigate the clinicopathological and prognostic impact of B-cell linker (BLNK) protein expression in colorectal cancer (CRC) as its function in CRC remains unexplored. We performed immunohistochemical staining for BLNK using tissue microarrays of 418 consecutive CRC samples; of these 10 were excluded due to inappropriate staining. The expression intensity and staining level was scored as 0-3 and 0-4, respectively, based on the percentage of positive cells. The immunoreactivity score (IRS) was calculated by multiplying these two scores. BLNK expression was observed in 222 patients (54.4 %). Lymph node metastasis (p = 0.031), right colon cancer (p = 0.026), mutinous adenocarcinoma (p < 0.001), and perineural invasion (p = 0.049) were more frequently observed in the IRS 4-12 group than in the IRS 0-3 group. At the same cutoff point, the 5-year recurrence-free survival rate of the patients with stage HI was significantly lower than that observed in IRS 4-12 group (74.8 % +/- 4.2 % vs. 54.2 +/- 8.5 %, p = 0.003). Multivariate analysis revealed IRS 4-12 to be an independent risk factor for recurrence (Hazard ratio 2.346, 95 % confidence interval 1.348-4.085, p = 0.003). In conclusion, overexpression of BLNK protein is an independent risk factor for CRC recurrence. | en_US |
dc.description.sponsorship | This work was supported by the research fund of Hanyang University (HY-2015). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER GMBH | en_US |
dc.subject | BLNK | en_US |
dc.subject | Colorectal | en_US |
dc.subject | Adenocarcinoma | en_US |
dc.subject | Lymph node metastasis | en_US |
dc.subject | Prognosis | en_US |
dc.title | Prognostic value of B-cell linker protein in colorectal cancer | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 216 | - |
dc.identifier.doi | 10.1016/j.prp.2020.152821 | - |
dc.relation.page | 1-5 | - |
dc.relation.journal | PATHOLOGY RESEARCH AND PRACTICE | - |
dc.contributor.googleauthor | Lee, Jun Ho | - |
dc.contributor.googleauthor | Lee, Ju-Hee | - |
dc.contributor.googleauthor | Ahn, Byung Kyu | - |
dc.contributor.googleauthor | Paik, Seung Sam | - |
dc.contributor.googleauthor | Lee, Kang Hong | - |
dc.relation.code | 2020046525 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | bkahn | - |
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