Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jong Wook Hong | - |
dc.date.accessioned | 2021-08-10T05:50:55Z | - |
dc.date.available | 2021-08-10T05:50:55Z | - |
dc.date.issued | 2020-06 | - |
dc.identifier.citation | BIOTECHNOLOGY AND BIOENGINEERING, v. 117, no. 9, page. 2658-2667 | en_US |
dc.identifier.issn | 1097-0290 | - |
dc.identifier.issn | 0006-3592 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/full/10.1002/bit.27447 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/163434 | - |
dc.description.abstract | The emerging field of regenerative medicine has revealed that the exosome contributes to many aspects of development and disease through intercellular communication between donor and recipient cells. However, the biological functions of exosomes secreted from cells have remained largely unexplored. Here, we report that the human hepatic progenitor cells (CdHs)-derived exosome (EXOhCdHs) plays a crucial role in maintaining cell viability. The inhibition of exosome secretion treatment with GW4869 results in the acceleration of reactive oxygen species (ROS) production, thereby causing a decrease of cell viability. This event provokes inhibition of caspase dependent cell death signaling, leading to a ROS-dependent cell damage response and thus induces promotion of antioxidant gene expression or repair of cell death of hypoxia-exposed cells. Together, these findings show the effect of exosomes in regeneration of liver cells, and offer valuable new insights into liver regeneration. | en_US |
dc.description.sponsorship | This study was supported by the Basic Science Research Program (2018R1A2B6005354 to J. W. H.) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, the Future Planning of Korea and National Research Foundation of Korea (NRF-2018M3A9H1023323 to J. W. H., NRF-2018M3A9H1023910 to D. C.) and Grants from the Medical Research Center (2017R1A5A2015395 to D. C.). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | WILEY | en_US |
dc.title | Exosomes derived from chemically induced human hepatic progenitors inhibit oxidative stress induced cell death | en_US |
dc.type | Article | en_US |
dc.relation.no | 9 | - |
dc.relation.volume | 117 | - |
dc.identifier.doi | 10.1002/bit.27447 | - |
dc.relation.page | 2658-2667 | - |
dc.relation.journal | BIOTECHNOLOGY AND BIOENGINEERING | - |
dc.contributor.googleauthor | Hyung, S. | - |
dc.contributor.googleauthor | Shin, K. | - |
dc.contributor.googleauthor | Kim, J.Y. | - |
dc.contributor.googleauthor | Hong, J.W. | - |
dc.contributor.googleauthor | Jeong, J. | - |
dc.contributor.googleauthor | Yim, J.-H. | - |
dc.contributor.googleauthor | Choi, D. | - |
dc.contributor.googleauthor | Yu, C.J. | - |
dc.contributor.googleauthor | Jung, H.S. | - |
dc.contributor.googleauthor | Hwang, K.-G. | - |
dc.relation.code | 2020051769 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF ENGINEERING SCIENCES[E] | - |
dc.sector.department | DEPARTMENT OF BIONANO ENGINEERING | - |
dc.identifier.pid | jwh | - |
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