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dc.contributor.author양철수-
dc.date.accessioned2021-07-22T05:23:06Z-
dc.date.available2021-07-22T05:23:06Z-
dc.date.issued2020-03-
dc.identifier.citationTHERANOSTICS, v. 10, no. 9, page. 3892-3904en_US
dc.identifier.issn1838-7640-
dc.identifier.urihttps://www.thno.org/v10p3892.htm-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/163079-
dc.description.abstractImmunosuppressive drugs are crucial for preventing acute graft rejection or autoimmune diseases. They are generally small molecules that require suitable drug carriers for ensuring stability, bioavailability, and longer half-life. Mycophenolic acid (MPA) is an extensively studied immunosuppressive drug. However, it requires suitable carriers for overcoming clinical limitations. Currently, lipid-shelled micro- and nanobubbles are being thoroughly investigated for diagnostic and therapeutic applications, as they possess essential properties, such as injectability, smaller size, gaseous core, high surface area, higher drug payload, and enhanced cellular penetration. Phospholipids are biocompatible and biodegradable molecules, and can be functionalized according to specific requirements. Methods: In this study, we synthesized oxygen nanobubbles (ONBs) and loaded the hydrophobic MPA within the ONBs to generate ONB/MPA. Peripheral blood mononuclear cells (PBMCs) were treated with ONB/MPA to determine the suppression of immune response by measuring cytokine release. In vivo murine experiments were performed to evaluate the effectiveness of ONB/MPA in the presence of inflammatory stimulants. Results: Our results suggest that ONBs successfully delivered MPA and reduced the release of cytokines, thereby controlling inflammation and significantly increasing the survival rate of animals. Conclusion: This method can be potentially used for implantation and for treating autoimmune diseases, wherein immunosuppression is desired.en_US
dc.description.sponsorshipThis study was supported by the Nano-Material Technology Development Program and the Basic Research Program through the National Research Foundation of Korea (NRF), funded by the Korean government (No. 2017M3A7B8061942, 2019R1A2C 1006018, and 2019R1I1A2A01064237).en_US
dc.language.isoen_USen_US
dc.publisherIvyspring International Publisheren_US
dc.subjectmycophenolic aciden_US
dc.subjectoxygen nanobubblesen_US
dc.subjectimmunosuppressionen_US
dc.subjectperipheral blood mononuclear cellsen_US
dc.subjectinflammationen_US
dc.subjectautoimmune diseasesen_US
dc.titleEffective delivery of mycophenolic acid by oxygen nanobubbles for modulating immunosuppressionen_US
dc.typeArticleen_US
dc.relation.no9-
dc.relation.volume10-
dc.identifier.doi10.7150/thno.41850-
dc.relation.page3892-3904-
dc.relation.journalTHERANOSTICS-
dc.contributor.googleauthorKhan, M.S.-
dc.contributor.googleauthorHwang, J.-
dc.contributor.googleauthorChoi, Y.-
dc.contributor.googleauthorLee, K.-
dc.contributor.googleauthorKwon, Y.-
dc.contributor.googleauthorJang, J.-
dc.contributor.googleauthorYoon, S.-
dc.contributor.googleauthorChoi, J.-
dc.contributor.googleauthorKim, J.-S.-
dc.contributor.googleauthorYang, C.-S.-
dc.relation.code2020045642-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E]-
dc.sector.departmentDEPARTMENT OF MOLECULAR AND LIFE SCIENCE-
dc.identifier.pidchulsuyang-


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