Dietary schizophyllan reduces mitochondrial damage by activating SIRT3 in mice
- Title
- Dietary schizophyllan reduces mitochondrial damage by activating SIRT3 in mice
- Author
- 양철수
- Issue Date
- 2020-03
- Publisher
- PHARMACEUTICAL SOC KOREA
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v. 43, no. 4, Page. 449-461
- Abstract
- Schizophyllan (SPG), produced by Schizophyllum commune, is an exopolysaccharide with multiple academic and commercial uses, including in the food industry and for various medical functions. We previously demonstrated that SPG conjugated with c-Src peptide exerted a significant therapeutic effect on mouse models of the acute inflammatory diseases polymicrobial sepsis and ulcerative colitis. Here we extended these results by investigating whether SPG exerted a protective effect against mitochondrial damage in the liver via sirtuin 3 (SIRT3) induction, focusing on the deacetylation of succinate dehydrogenase A (SDHA) and superoxide dismutase 2 (SOD2). Liver damage models induced by alcohol or conjugated linoleic acid (CLA, which simulates lipodystrophy) in SIRT3(-/-), SOD2(-/-), and SDHA(-/-) mice were used. Results showed that dietary supplementation with SPG induced SIRT3 activation
- URI
- https://www.scopus.com/record/display.uri?eid=2-s2.0-85082610827&origin=inward&txGid=d6dab93a79bbb8190b4b7a053c06d30chttps://repository.hanyang.ac.kr/handle/20.500.11754/163028
- ISSN
- 1976-3786; 0253-6269
- DOI
- 10.1007/s12272-020-01231-4
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MOLECULAR AND LIFE SCIENCE(분자생명과학과) > Articles
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