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dc.contributor.author이영한-
dc.date.accessioned2021-07-21T04:42:18Z-
dc.date.available2021-07-21T04:42:18Z-
dc.date.issued2000-09-
dc.identifier.citationEUROPEAN JOURNAL OF BIOCHEMISTRY, v. 271, issue. 17, page. 3470-3480en_US
dc.identifier.issn0014-2956-
dc.identifier.urihttp://eds.a.ebscohost.com/eds/detail/detail?vid=0&sid=0165e8b9-2d01-42fd-8334-4808dbd6744f%40sdc-v-sessmgr02&bdata=Jmxhbmc9a28mc2l0ZT1lZHMtbGl2ZQ%3d%3d#AN=14173508&db=a9h-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/162864-
dc.description.abstractWe show that epigallocatechin-3 gallate (EGCG), a major component of green tea, stimulates phospholipase D (PLD) activity in U87 human astroglioma cells. EGCG-induced PLD activation was abolished by the phospholipase C (PLC) inhibitor and a lipase inactive PLC-gamma1 mutant, which is dependent on intracellular or extracellular Ca(2+), with the possible involvement of Ca(2+)/calmodulin-dependent protein kinase II (CaM kinase II). EGCG induced translocation of PLC-gamma1 from the cytosol to the membrane and PLC-gamma1 interaction with PLD1. EGCG regulates the activity of PLD by modulating the redox state of the cells, and antioxidants reverse this effect. Moreover, EGCG-induced PLD activation was reduced by PKC inhibitors or down-regulation of PKC. Taken together, these results show that, in human astroglioma cells, EGCG regulates PLD activity via a signaling pathway involving changes in the redox state that stimulates a PLC-gamma1 [Ins(1,4,5)P(3)-Ca(2+)]-CaM kinase II-PLD pathway and a PLC-gamma1 (diacylglycerol)-PKC-PLD pathway.en_US
dc.language.isoen_USen_US
dc.publisherBLACKWELL SCIENCE LTDen_US
dc.titlePhospholipase C, protein kinase C, Ca2+/calmodulin-dependent protein kinase II, and redox state are involved in epigallocatechin gallate-induced phospholipase D activation in human astroglioma cells.en_US
dc.typeArticleen_US
dc.identifier.doi10.1111/j.0014-2956.2004.04242.x-
dc.relation.journalEUROPEAN JOURNAL OF BIOCHEMISTRY-
dc.contributor.googleauthorKim, Shi Yeon-
dc.contributor.googleauthorAhn, Bong-Hyun-
dc.contributor.googleauthorKim, Joonmo-
dc.contributor.googleauthorBae, Yoe-Sik-
dc.contributor.googleauthorKwak, Iong-Young-
dc.contributor.googleauthorMin, Gyesik-
dc.contributor.googleauthorKwon, Taeg Kyu-
dc.contributor.googleauthorChang, Jong-Soo-
dc.contributor.googleauthorLee, Young Han-
dc.contributor.googleauthorYoon, Shin-Hee-
dc.contributor.googleauthorMin, Do Sik-
dc.relation.code2012202992-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF SCIENCE & TECHNOLOGY[E]-
dc.sector.departmentDIVISION OF MOLECULAR & LIFE SCIENCE-
dc.identifier.pidyounghan-
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COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > ETC
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