Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이영한 | - |
dc.date.accessioned | 2021-07-21T04:42:18Z | - |
dc.date.available | 2021-07-21T04:42:18Z | - |
dc.date.issued | 2000-09 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF BIOCHEMISTRY, v. 271, issue. 17, page. 3470-3480 | en_US |
dc.identifier.issn | 0014-2956 | - |
dc.identifier.uri | http://eds.a.ebscohost.com/eds/detail/detail?vid=0&sid=0165e8b9-2d01-42fd-8334-4808dbd6744f%40sdc-v-sessmgr02&bdata=Jmxhbmc9a28mc2l0ZT1lZHMtbGl2ZQ%3d%3d#AN=14173508&db=a9h | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/162864 | - |
dc.description.abstract | We show that epigallocatechin-3 gallate (EGCG), a major component of green tea, stimulates phospholipase D (PLD) activity in U87 human astroglioma cells. EGCG-induced PLD activation was abolished by the phospholipase C (PLC) inhibitor and a lipase inactive PLC-gamma1 mutant, which is dependent on intracellular or extracellular Ca(2+), with the possible involvement of Ca(2+)/calmodulin-dependent protein kinase II (CaM kinase II). EGCG induced translocation of PLC-gamma1 from the cytosol to the membrane and PLC-gamma1 interaction with PLD1. EGCG regulates the activity of PLD by modulating the redox state of the cells, and antioxidants reverse this effect. Moreover, EGCG-induced PLD activation was reduced by PKC inhibitors or down-regulation of PKC. Taken together, these results show that, in human astroglioma cells, EGCG regulates PLD activity via a signaling pathway involving changes in the redox state that stimulates a PLC-gamma1 [Ins(1,4,5)P(3)-Ca(2+)]-CaM kinase II-PLD pathway and a PLC-gamma1 (diacylglycerol)-PKC-PLD pathway. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | BLACKWELL SCIENCE LTD | en_US |
dc.title | Phospholipase C, protein kinase C, Ca2+/calmodulin-dependent protein kinase II, and redox state are involved in epigallocatechin gallate-induced phospholipase D activation in human astroglioma cells. | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1111/j.0014-2956.2004.04242.x | - |
dc.relation.journal | EUROPEAN JOURNAL OF BIOCHEMISTRY | - |
dc.contributor.googleauthor | Kim, Shi Yeon | - |
dc.contributor.googleauthor | Ahn, Bong-Hyun | - |
dc.contributor.googleauthor | Kim, Joonmo | - |
dc.contributor.googleauthor | Bae, Yoe-Sik | - |
dc.contributor.googleauthor | Kwak, Iong-Young | - |
dc.contributor.googleauthor | Min, Gyesik | - |
dc.contributor.googleauthor | Kwon, Taeg Kyu | - |
dc.contributor.googleauthor | Chang, Jong-Soo | - |
dc.contributor.googleauthor | Lee, Young Han | - |
dc.contributor.googleauthor | Yoon, Shin-Hee | - |
dc.contributor.googleauthor | Min, Do Sik | - |
dc.relation.code | 2012202992 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE & TECHNOLOGY[E] | - |
dc.sector.department | DIVISION OF MOLECULAR & LIFE SCIENCE | - |
dc.identifier.pid | younghan | - |
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