142 54

The utility of histological subtype for predicting survival of lung cancer patients with rheumatoid arthritis

Title
The utility of histological subtype for predicting survival of lung cancer patients with rheumatoid arthritis
Author
박동원
Keywords
Lung cancer; rheumatoid arthritis (RA); survival; small cell lung cancer (SCLC); non-small cell lung cancer (NSCLC)
Issue Date
2020-03
Publisher
AME PUBL CO
Citation
TRANSLATIONAL CANCER RESEARCH, v. 9, no. 4, page. 2627-2637
Abstract
Background: This study determined whether the survival of lung cancer (LC) patients with rheumatoid arthritis (RA) is differed by histological subtype. Materials: This observational, retrospective study compared the LC survival rate of 34 RA patients with that of 132 age- and sex-matched patients without RA who received medical care from 2011 to 2016. Survival curves were generated using the Kaplan-Meier method. Cox proportional hazards regression analyses were used to estimate hazard ratios and determine risk factors predicting mortality according to histological subtype, including small cell lung cancer (SCLC), and non-small cell lung cancer (NSCLC). Results: The predominant histological subtype was adenocarcinoma in both groups, however, a larger proportion of SCLC patients was noted in patients with both LC and RA, compared to those with LC but without RA (26.5% vs. 12.9%, respectively; P=0.0317). LC patients with RA had a significantly lower body mass index (P=0.0488), and a higher proportion of interstitial lung disease (P<0.0001), compared to patients without RA. There was no statistical difference in the distribution of smoking status, stage, or comorbidity index between groups. Overall survival did not differ between LC patients with and without RA. Mortality was significantly worse for RA patients with SCLC than those with NSCLC (P=0.0404), and RA was associated with a 3.26-fold increase in mortality for SCLC patients with versus without RA (P=0.0350; 95% confidence interval: 1.05-9.56). However, RA was not a risk factor for mortality in NSCLC and, even in histological subtypes including lung adenocarcinoma and squamous cell carcinoma. Conclusions: RA was not associated with a lower overall survival rate for LC patients, irrespective of histological subtype. Because the effects of RA on LC mortality might differ between SCLC and NSCLC patients, future studies should recognize that the histological subtype may affect the outcome.
URI
https://tcr.amegroups.com/article/view/37099/htmlhttps://repository.hanyang.ac.kr/handle/20.500.11754/162820
ISSN
2218-676X; 2219-6803
DOI
10.21037/tcr.2020.03.02
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
The utility of histological subtype for predicting survival of lung cancer patients with rheumatoid arthritis.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE