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Effect of Human Mesenchymal Stem Cells on Xenogeneic T and B Cells Isolated from Lupus-Prone MRL.Fas(lpr) Mice

Title
Effect of Human Mesenchymal Stem Cells on Xenogeneic T and B Cells Isolated from Lupus-Prone MRL.Fas(lpr) Mice
Author
배상철
Keywords
INTERFERON-GAMMA; ANTIBODY-PRODUCTION; STROMAL CELLS; PROLIFERATION; INHIBITION; MODEL; 2,3-DIOXYGENASE; DIFFERENTIATION; FAIL
Issue Date
2020-03
Publisher
HINDAWI LTD
Citation
STEM CELLS INTERNATIONAL, v. 2020, article no. 5617192
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease, which is characterized by hyperactivation of T and B cells. Human mesenchymal stem cells (hMSCs) ameliorate the progression of SLE in preclinical studies using lupus-prone MRL.Fas(lpr) mice. However, whether hMSCs inhibit the functions of xenogeneic mouse T and B cells is not clear. To address this issue, we examined the in vitro effects of hMSCs on T and B cells isolated from MRL.Fas(lpr) mice. Naive hMSCs inhibited the functions of T cells but not B cells. hMSCs preconditioned with IFN-gamma (i) inhibited the proliferation of and IgM production by B cells, (ii) attracted B cells for cell-cell interactions in a CXCL10-dependent manner, and (iii) inhibited B cells by producing indoleamine 2,3-dioxygenase. In summary, our data demonstrate that hMSCs exert therapeutic activity in mice in three steps: first, naive hMSCs inhibit the functions of T cells, hMSCs are then activated by IFN-gamma, and finally, they inhibit B cells.
URI
https://www.hindawi.com/journals/sci/2020/5617192/https://repository.hanyang.ac.kr/handle/20.500.11754/162786
ISSN
1687-966X; 1687-9678
DOI
10.1155/2020/5617192
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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