Immunological characterization of 130 kDa phospholipase C-beta4 isozyme in rat cerebellar purkinje cells.
- Title
- Immunological characterization of 130 kDa phospholipase C-beta4 isozyme in rat cerebellar purkinje cells.
- Author
- 이영한
- Keywords
- Phosphoinositide-specific phospholipase C; Purkinje cell; Immunohistochemistry; Monoclonal antibody; Phospholipase C-β4
- Issue Date
- 2000-09
- Publisher
- ELSEVIER SCI IRELAND LTD
- Citation
- NEUROSCIENCE LETTERS, v. 292, no. 1, page. 9-12
- Abstract
- We have developed a monoclonal antibody, β4-22-9 that recognizes an epitope on pleckstrin homology (PH) domain (1–136 amino acids) located at the amino terminus of rat 130 kDa phospholipase C-β4 (PLC-β4). Tissue distribution of 130 kDa PLC-β4 was determined with this monoclonal antibody. One hundred and thirty kiloDalton PLC-β4 was exclusively expressed in the nervous tissues including cerebellum and cerebrum, especially at very high levels in cerebellum. The expression of 130 kDa PLC-β4 in cerebellum was gradually increased from 5 days after birth to adulthood. In the adult cerebellum, especially high level of 130 kDa PLC-β4 was localized on the periphery of Purkinje cells in the patch-like pattern. These data implies that 130 kDa PLC-β4 may a role in cerebellar Purkinje cells.
- URI
- https://www.sciencedirect.com/science/article/pii/S0304394000014191https://repository.hanyang.ac.kr/handle/20.500.11754/162625
- ISSN
- 0304-3940
- DOI
- 10.1016/s0304-3940(00)01419-1
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > ETC
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