Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이영한 | - |
dc.date.accessioned | 2021-06-29T02:27:13Z | - |
dc.date.available | 2021-06-29T02:27:13Z | - |
dc.date.issued | 2000-10 | - |
dc.identifier.citation | MOLECULES AND CELLS, v. 10, no. 4, page. 469-474 | en_US |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | http://eds.b.ebscohost.com/eds/detail/detail?vid=0&sid=0e6686a6-d339-4830-8b69-2bad99d54c48%40sessionmgr102&bdata=Jmxhbmc9a28mc2l0ZT1lZHMtbGl2ZQ%3d%3d#db=a9h&AN=9170356 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/162510 | - |
dc.description.abstract | Phospholipase C (PLC)-r1 plays a pivotal role in the signal transduction pathway mediated by growth factors. In this study, we found that neurite outgrowth of pheochromocytoma (PC12) cells was significantly induced by interleukin-6 (IL-). Stimulation of PC12 cells with IL-6 led to tyrosine phosphorylation of PLC-r1 in a dose- and time-dependent manner. IL-6 stimulation also increased the hydrolysis of phosphorylation of PLC-r1 was inhibited by the pretreatment of protein kinase inhibitors such as genisteim and staurosporine. These results suggest that PLC-r1 may be in volved in the signal transduction pathway of IL-6-induced PC12 cell differentiation. | en_US |
dc.description.sponsorship | This work was supported by Korea Science and Engineering Foundation (KOSEF) through the Center for Cell Signaling Research at Ewha Woman University(98-0403-08-10-5) and by Brain Science& Engineering Research Program (98-J04-02-01-A-03) of the Ministry of Science and Teachnology in Korea. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | SPRINGER-VERLAG SINGAPORE PTE LTD(한국분자세포생물학회) | en_US |
dc.subject | Interleukin-6 | en_US |
dc.subject | PC12 Cells | en_US |
dc.subject | Phospholipase C-r1 | en_US |
dc.subject | Signal Transduction | en_US |
dc.subject | Tyrosine phosphorylation. | en_US |
dc.title | Interleukin-6-induced tyrosine phosphorylation of phospholipase C-γ1 in PC12 cells. | en_US |
dc.type | Article | en_US |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.contributor.googleauthor | Lee, Young Han | - |
dc.contributor.googleauthor | Bae, Sun Sik | - |
dc.contributor.googleauthor | Seo, Jeong Kon | - |
dc.contributor.googleauthor | Choi, Inpyo | - |
dc.contributor.googleauthor | Ryu, Sung Ho | - |
dc.contributor.googleauthor | Suh, Pann-Ghill | - |
dc.relation.code | 2007206841 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE & TECHNOLOGY[E] | - |
dc.sector.department | DIVISION OF MOLECULAR & LIFE SCIENCE | - |
dc.identifier.pid | younghan | - |
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