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A short synthesis of (±)-laurene: mechanistic reinvestigation in palladium-catalyzed cycloreduction of 1,6-enynes

Title
A short synthesis of (±)-laurene: mechanistic reinvestigation in palladium-catalyzed cycloreduction of 1,6-enynes
Author
원호식
Issue Date
2000-12
Publisher
American Chemical Society
Citation
Tetrahedron Letters, v. 41, issue. 21, page. 8365-8369
Abstract
Two palladium-catalyzed cycloreduction strategies have been applied for the synthesis of laurene. Palladium-catalyzed cyclizations of 1,6-enynes initially form the corresponding alkylpalladium intermediates. While triethylsilane could directly reduce the intermediates to lead to the corresponding cycloreduced products, the intermediates in the presence of even excess formic acid underwent β-elimination to yield the dienes that were further reduced at the less hindered olefins to yield the cycloreduced products.
URI
https://www.sciencedirect.com/science/article/pii/S0040403900014842https://repository.hanyang.ac.kr/handle/20.500.11754/162331
ISSN
0040-4039
DOI
10.1016/S0040-4039(00)01484-2
Appears in Collections:
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > CHEMICAL AND MOLECULAR ENGINEERING(화학분자공학과) > Articles
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