Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수재 | - |
dc.date.accessioned | 2021-05-18T08:04:34Z | - |
dc.date.available | 2021-05-18T08:04:34Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | NEURO-ONCOLOGY, v. 22, no. 10, page. 1452-1462 | en_US |
dc.identifier.issn | 1522-8517 | - |
dc.identifier.issn | 1523-5866 | - |
dc.identifier.uri | https://academic.oup.com/neuro-oncology/article/22/10/1452/5808804 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/162288 | - |
dc.description.abstract | Background. Mesenchymal stemlike cells (MSLCs) have been detected in many types of cancer including brain tumors and have received attention as stromal cells in the tumor microenvironment. However, the cellular mechanisms underlying their participation in cancer progression remain largely unexplored.The aim of this study was to determine whether MSLCs have a tumorigenic role in brain tumors. Methods. To figure out molecular and cellular mechanisms in glioma invasion, we have cultured glioma with MSLCs in a co-culture system. Results. Here, we show that MSLCs in human glioblastoma (GBM) secrete complement component C5a, which is known for its role as a complement factor. MSLC-secreted C5a increases expression of zinc finger E-box-binding homeobox 1 (ZEB1) via activation of p38 mitogen-activated protein kinase (MAPK) in GBM cells, thereby enhancing the invasion of GBM cells into parenchymal brain tissue. Conclusion. Our results reveal a mechanism by which MSLCs undergo crosstalk with GBM cells through the C5a/ p38 MAPK/ZEB1 signaling loop and act as a booster in GBM progression. | en_US |
dc.description.sponsorship | This study was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (No.2019M3E5D1A01069361), National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (NRF-2019R1A2C3004155), and a grant of the Korea Health Technology, R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI14C1324). | en_US |
dc.language.iso | en | en_US |
dc.publisher | OXFORD UNIV PRESS INC | en_US |
dc.subject | C5a | en_US |
dc.subject | glioblastoma | en_US |
dc.subject | invasiveness | en_US |
dc.subject | mesenchymal stem-like cells | en_US |
dc.subject | tumor microenvironment | en_US |
dc.title | Crosstalk between GBM cells and mesenchymal stemlike cells promotes the invasiveness of GBM through the C5a/p38/ZEB1 axis | en_US |
dc.type | Article | en_US |
dc.relation.no | 10 | - |
dc.relation.volume | 22 | - |
dc.identifier.doi | 10.1093/neuonc/noaa064 | - |
dc.relation.page | 1452-1462 | - |
dc.relation.journal | NEURO-ONCOLOGY | - |
dc.contributor.googleauthor | Lim, Eun-Jung | - |
dc.contributor.googleauthor | Kim, Seungmo | - |
dc.contributor.googleauthor | Oh, Yoonjee | - |
dc.contributor.googleauthor | Suh, Yongjoon | - |
dc.contributor.googleauthor | Kaushik, Neha | - |
dc.contributor.googleauthor | Lee, Ji-Hyun | - |
dc.contributor.googleauthor | Lee, Hae-June | - |
dc.contributor.googleauthor | Kim, Min-Jung | - |
dc.contributor.googleauthor | Park, Myung-Jin | - |
dc.contributor.googleauthor | Lee, Su-Jae | - |
dc.relation.code | 2020048709 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | sj0420 | - |
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